Intradermal shots could stretch flu vaccine supply

first_imgNov 4, 2004 (CIDRAP News) – Two studies just published by the New England Journal of Medicine (NEJM) suggest that injecting influenza vaccine just beneath the skin surface, instead of into muscle, may be a way to stretch flu vaccine supplies without sacrificing protection.In one study, young adults who received one fifth of the standard vaccine dose in an intradermal shot showed at least as strong an immune response as others who received full-dose intramuscular shots.In the second study, intradermal vaccination with 40% of a standard dose worked just as well as a standard intramuscular dose in adults aged 18 to 60. However, older adults showed a somewhat less vigorous response to the reduced intradermal dose.”In times of shortage such as the present, intradermal vaccination of healthy young persons with reduced-dose inactivated influenza vaccine could be considered in order to stretch vaccine supplies,” write Robert Belshe, MD, and colleagues, authors of the second study. NEJM published both studies online as early-release articles.Intradermal vaccination involves inserting a needle 1 to 2 mm into the skin, according to the two reports. The method has been used with some success for hepatitis B and rabies vaccinations, but it is not approved for flu vaccination in the United States.The study using young adults was conducted by a Gaithersburg, Md., company called Iomai, which is developing vaccine skin patches. Richard T. Kenney, MD, and colleagues recruited 100 healthy adults ranging from 18 to 40 years old and randomly assigned them to receive either a standard intramuscular dose of trivalent flu vaccine (15 micrograms [mcg] of hemagglutinin per strain) or a single intradermal dose at about 20% strength (3 mcg of hemagglutinin per strain).As measured by increases in hemagglutination-inhibition titers 21 days after vaccination, the immune response in the intradermal group was similar to or better than that in the intramuscular group, the report says. Those who received intradermal shots had more local reactions to the vaccine, but the reactions were mild and transient.The authors write that using reduced-dose intradmeral shots “is particularly appealing, because standard tuberculin syringes and needles can be used with multidose vials of influenza [vaccine] to increase the supply of influenza vaccine by a factor about five.” But they add that further studies are needed to show the “wide-ranging relevance” of the technique.In the other study, researchers from Saint Louis University, the University of Rochester, and GlaxoSmithKline assigned two groups of 119 people each to receive trivalent flu vaccine by intradermal or intramuscular injection. The intradermal shots contained 6 mcg of hemagglutinin for each strain, while the intramuscular shot contained the standard dose of 15 mcg for each strain. Each group was divided into younger and older subgroups—18 to 60 years and older than 60.In the younger people, the two injection methods both yielded serum antibody responses that were “vigorous” and not significantly different. The older subgroups also had a strong antibody response to both types of vaccination, but the response was somewhat better in those who received intramuscular shots. However, the difference was significant only for one of the three viral strains in the vaccine (H3N2).As in the other study, local reactions to the injections were more common among the intradermal group than the intramuscular group, but they were mostly mild.The authors suggest that the intradermal injections could be used for younger members of two of the groups assigned priority for flu vaccine in the current shortage: healthcare workers and close contacts of infants younger than 6 months. The researchers add that the intradermal technique is harder to learn than the standard technique, but vaccinators would be likely to use the method effectively after training.The two reports are hailed as significant in an accompanying editorial by the late John R. La Montagne, PhD, and Anthony S. Fauci, MD, of the National Institute of Allergy and Infectious Diseases (NIAID). “Both of the current studies clearly show that intradermal vaccination may have greater immunogenicity than intramuscular vaccination,” they write. (La Montagne, who was deputy director of the NIAID, died suddenly this week.)On the basis of the two new studies and previous reports on intradermal immunization, “It is becoming clear that use of the intradermal route may at least partially overcome the relatively poor influenza-specific immune responses seen in certain at-risk populations, particularly the elderly,” La Montagne and Fauci write. They call for clinical trials in “a broad range of populations” to pave the way for approval of intradermal vaccination for flu.Kenney RT, Frech SA, Muenza LR, et al. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 2004;351(22) (published online Nov 3) [Full text]Belshe RB, Newman FK, Cannon J, et al. Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 2004;351(22) (published online Nov 3) [Full text]last_img read more

Constitutional Court bill would scrap term limits, allow justices to serve until age 70

first_imgLegal expert Erwin Natosmal Oemar of the Indonesian Public Interest Lawyer Network (PILNET) said there was no urgency for the House to deliberate the bill, especially while the country scrambled to contain the novel coronavirus pandemic.Erwin further argued that the draft bill reflected a conflict of interest. “It was created only to extend the term of office for justices who will soon retire,” he told The Jakarta Post.Arsul Sani of House Commission III overseeing legal affairs said the bill was initiated by Baleg and that the commission would continue the deliberation.”Lawmakers in Commission III will discuss the bill and critique it. [The draft] still can change. We welcome public criticism,” he told the Post on Thursday.Similarly, Commission III lawmaker Taufik Basari, who is also member of Baleg, said the contents of the bill could still develop.”The current draft is still very open for further discussion. It is only a proposal,” he said.Topics : The House of Representatives is planning to revise the Constitutional Court law, seeking to scrap the ten-year term limit for justices and instead set a retirement age of 70 for all members of the nine-justice bench.According to the draft bill, a copy of which was obtained by The Jakarta Post, the revisions focus on the change of tenure for the justices as well as the eligible age for a candidate to be selected as a Constitutional Court justice.Article 23 point 1 of the draft bill stipulates that Constitutional Court justices must retire at 70 years of age. The bill scraps the existing provision in Article 22, which stipulates that justices will serve for five years and can be reappointed for only one additional five-year term. Article 4 of the draft bill extends the tenure of the Constitutional Court chief justice and deputy justice to five years from the current 2.5 years.The bill also increases the minimum age for a person to be eligible for the position of Constitutional Court justice from the existing 47 years of age to 60 as seen in Article 15 point 2 of the draft bill.House Legislation Body (Baleg) deputy chairman Willy Aditya of the NasDem Party said the bill was one of seven currently being discussed by lawmakers, which also included the omnibus bill on job creation, the indigenous peoples bill and the state civil apparatus (ASN) bill.Critics, however, argue that the bill does not touch the substance of the problems in the Constitutional Court as it focuses only on the tenure of justices.last_img read more

Virus-hit Singapore economy to shrink up to 7%: govt

first_img“Second, a growing perception of diminished fiscal and monetary policy space in many major economies could damage confidence in authorities’ ability to respond to shocks.”The economy is now expected to contract by up to 7.0 percent instead of 4.0 percent as projected in March “in view of the deterioration in the external demand outlook” and the partial lockdown imposed domestically, the ministry said.”Notwithstanding the downgrade, there continues to be a significant degree of uncertainty over the length and severity of the COVID-19 outbreak, as well as the trajectory of the economic recovery,” it warned.Singapore’s central bank in March eased monetary policy to support the virus-hit economy.Topics : Officials say they may start relaxing the rules from early June but many restrictions will remain.Lockdowns to contain the virus in major markets such as the United States, Europe and China have crippled demand for exports, and a halt in international air travel has hammered Singapore’s key tourism sector.”There remain significant uncertainties in the global economy,” the trade ministry said in a statement.”First, there is a risk that subsequent waves of infections in major economies such as the US and Eurozone may further disrupt economic activity,” it said. Singapore’s economy, a bellwether for global trade, could shrink by as much as 7.0 percent this year, as the coronavirus pandemic throttles demand, the government said Tuesday.The trade ministry downgraded its forecast as official data showed gross domestic product (GDP) fell by 0.7 percent year-on-year in the first quarter to March, and by 4.7 percent compared with the previous quarter.Like many other countries, Singapore has ordered the closure of most businesses, advised people to stay at home, and banned large gatherings.last_img read more

Governor Wolf Signs Animal Cruelty Prevention Bill

first_imgGovernor Wolf Signs Animal Cruelty Prevention Bill June 28, 2017 Animal Welfare,  Bill Signing,  Environment,  Press Release,  Results Harrisburg, PA – Governor Tom Wolf today signed the animal cruelty prevention bill at a public celebration surrounded by advocates and members of the legislature.Act 10, House Bill 1238, was introduced by Rep. Todd Stephens, and updates and clarifies the existing animals abuse statutes and increases the penalties for abusing animals.“I am proud to sign the Animal Abuse Statute Overhaul into effect today, strengthening the penalty for animal abuse and neglect in the Commonwealth of Pennsylvania,” said Governor Wolf. “Today is a day of celebration for all Pennsylvanians, and animal-lovers everywhere and I am proud to be a part of the true collaboration that helped make this landmark legislation a reality.”The overhaul bill includes:mandatory forfeiture of the abused animal to an animal shelter if the abuser is convictedstipulations to dog tetheringincreased protection for horsescivil immunity for veterinarians, veterinarian technicians, and humane society police officers to prevent frivolous lawsuits against these professionals when reporting animal cruelty in good faith“Today we are sending a clear message that Pennsylvania will not tolerate animal cruelty in our state and will punish offenders to the fullest extent of the law,” Rep. Stephens said. “This is the most comprehensive animal protection bill in the Commonwealth’s history and would not have been possible without the determined efforts of my colleagues in the House and Senate, the Governor and the thousands of advocates who contacted their elected officials expressing their support for the bill.”“The story of Libre’s shocking mistreatment and miraculous recovery helped spur a broader discussion of how we can better protect animals,” said Sen. Rich Alloway. “The result is a bill that not only toughens penalties against abusers, but also spells out the kind of treatment that is dangerous and unacceptable. Our pets are part of our families and depend on us for their care, so it’s far past time that we ensure abusers face a punishment that matches the heinous nature of the crime.”“Governor Tom Wolf’s signature today on House Bill 1238 marks a new era in Pennsylvania,” Rep. Ryan Bizzarro said. “Act 10, which takes effect in 60 days, is literally a new lease on life for the animals that depend on us for care, comfort and compassion. “Act 10 will help put an end to instances of torture and extreme neglect that are too rampant. Our animal friends deserve better.”“The passing of House Bill 1238 is an historic legislative step toward protecting the animals of Pennsylvania from abuse and neglect. We applaud the Pennsylvania General Assembly for their wisdom and actions in humane leadership to move this legislation forward to Governor Wolf to sign into law,” said Kristen Tullo, Pennsylvania State Director, Humane Society of the United States. “Animal advocates from across the state and country deserve much credit as they joined forces in support of this legislation to make a difference toward passage of the bill.”center_img SHARE Email Facebook Twitterlast_img read more

QuickCar Racing Products quick to continue IMCA national champion awards

first_imgLEBANON, Tenn. – IMCA drivers planning to chase national championships didn’t have to wait long to learn that QuickCar Racing Products would continue its slate of awards for top drivers in all eight divisions.IMCA Modified, IMCA Sunoco Stock Car, IMCA Sunoco Hobby Stock, Karl Chevrolet North­ern SportMods and Smiley’s Racing Products Southern SportMods national champions all receive 3-gauge panels while the national Late Model champion gets a 4-gauge panel set and both the IMCA RaceSaver Sprint Car and Mach-1 Sport Compact national champions receive 2-gauge panel sets from the Lebanon, Tenn., manufacturer.Now in its sixth year of IMCA sponsorship, QuickCar introduced its understandably popular program of awards for national champions in 2015.Champions crowned during the IMCA Speedway Motors Super Nationals fueled by Casey’s take home QuickCar tachometers, as does the champion at the Sprint Nationals.National champions will receive their awards during the IMCA banquet in November. Su­per Nation­als and the Sprint Car Nationals awards will be presented in victory lane.QuickCar manufac­tures a wide variety of high performance products that also includes volt me­ters, water pressure kits, tachometers and switch panels.Information about the complete QuickCar line of products is available at the website, by calling 800 997-7333 and on Fa­cebook.“The renewal of the QuickCar program is great for us and just another reason to compete for a national championship in 2018,” IMCA Marketing Director Kevin Yoder said. “The battle will be wide open this year and we can anticipate it will come right down to the last weekend in September as it always does.”last_img read more

CAF Confederation Cup: Enyimba too strong for TS Galaxy

first_imgRelatedPosts Kano Pillars to play CAF Confederation Cup home matches away from home Perfect start for Nigeria’s Enyimba in CAF Confederation Cup CAF CC: Akwa United beat Al-Ittihad on penalties  TS Galaxy CAF Confederation Cup’s group stage hopes hang in the balance after going down 2-0 to Nigerian side Enyimba at Enyimba International Stadium on Sunday evening.The GladAfrica Championship side got to this stage of the tournament after thrashing CNaPs Sport 4-1 on aggregate in the preliminary round, while the Nigerian giants got the second bite of the cherry after being knocked out of the CAF Champions League by Al Hilal Omdurman in the first round.Galaxy were under siege in the early stages as Enyimba opened the scoring in the seventh, thanks to Victor Mbaoma, who struck home a cross inside the box, getting his first goal for the club.Dan Malesela’s charges were growing in the game halfway through the first stanza, impressing with their possession game and their first chance came three minutes before the break after Tshegofatso Nyama went through on goal but he struck his shot wide from close range.The Rockets were finding chances early in the second stanza, with the match stretching from end to end but the People’s Elephants got the second goal just after the hour-mark after Martins Usule nettted with a cracking strike.The game was opening up more in the latter phase, Enyimba carving out their opportunities, but goalkeeper Ludwe Mpakumpaku kept the score-line respectable as the visitors went down 2-0 in the end.Masalesa’s men will have a chance to overturn the tie when the sides clash in the second-leg next Sunday on South African soil. Tags: CAF Cofederation Cuplast_img read more

Manchester United face English FA charge for conduct against Liverpool

first_imgRelatedPosts Lampard: I still have confidence in Tomori Ighalo: My best moment as ‘Red Devil’ Mane double eases Liverpool to win over 10-man Chelsea Manchester United were charged by the Football Association in England on Tuesday for failing to ensure their players conducted themselves in an orderly fashion” in Sunday’s 2-0 defeat to Liverpool. The charge refers to Manchester United goalkeeper, David de Gea and a group of his team mates. They had confronted referee Craig Pawson after he originally awarded a goal by Roberto Firmino in the 25th minute. De Gea was booked for his protests after claiming he was fouled by Liverpool defender, Virgil van Dijk in the build-up. The goal was overturned by the video assistant referee. Manchester United have until Thursday to respond to the charge. Manchester United manager, Ole Gunnar Solskjaer, could meanwhile be without Swedish defender, Victor Lindelof for Wednesday’s home tie with Burnley after he was sent home ill from training earlier Tuesday.Tags: Craig PawsonDavid De GeaFALiverpoolManchester Unitedlast_img read more

MPA approves golf, XC, field hockey, soccer; football, volleyball moved to spring

first_img Hospice volunteers help families navigate grief and find hope – September 12, 2020 Latest Posts Bio ELLSWORTH — At long last, the verdict is in.High school sports will be offered in Maine this fall after the Maine Principals’ Association received approval from state agencies on a framework for a 2020 season, though not all activities have been cleared to return. Golf, cross-country, field hockey and soccer will be offered with football and volleyball set to be moved to early 2021.The MPA made the announcement Thursday, one day after the governing body met with the Maine School Superintendents Association and the Janet Mills administration to hash out the final parameters for the fall season. The MPA informed member schools of the decision in an email that included guidelines for a return to play for all sports.The MPA had previously recommended at its Aug. 27 meeting that all sports be offered for the fall season. Yet those plans changed five days later when Department of Health and Human Services Commissioner Jeanne Lambrew and Department of Education Commissioner Pender Makin informed the MPA that the proposal did not meet state guidelines on the return to community sports.This is placeholder textThis is placeholder textIn a joint statement, the commissioners referred to the newly approved guidelines as a “consensus” on a safe return to high school sports. Maine School Superintendents Association Executive Director Eileen King added that the guidelines were successful in balancing the resumption of athletics with educators’ efforts to resume in-class instruction.“As an extension of our educational programming, it is important both cocurricular and extracurricular activities are offered in a manner that is safe and consistent with the DHHS-approved community sports guidelines,” King said. “These activities, if offered under these guidelines, will help to promote the safety of all participants as well as the safety of the sponsoring schools.”Golf and cross-country, the two “low-risk” activities under the state’s guidelines on community sports, have been approved on a statewide basis. Field hockey and soccer, which are designated as “moderate-risk” sports, may return on a regional basis only. Soccer teams will not participate in postseason play this fall.In lieu of traditional football, schools may offer 7-on-7 touch or flag football as well as Ironman or punt-pass-and-kick competitions. MPA Executive Director Mike Burnham said the governing body will look to offer the sport “in the late winter [or] early spring,” though concerns remain regarding potential conflicts with other sports and the feasibility of playing an outdoor sport in the state’s colder, wetter months.The decision regarding football was deeply unpopular among high school players and parents. Sandy Irish and Melissa Poland, mothers of players at Edward Little High School in Auburn, urged those from across the state to join in a protest that was held Saturday morning on Longley Bridge.Bucksport’s Alexis Wardwell chases down Washington Academy’s Siobhan Duffy during a 2019 high school girls’ soccer game at Bucksport High School. Soccer, golf, cross-country and field hockey will be offered as part of the fall 2020 season. FILE PHOTO“The state’s COVID-19 infection rate is one of the lowest in the country, yet other contact sports are being allowed to play this fall,” Irish and Poland wrote in a statement inviting others to turn out for the protest. “We won’t stop, and we can’t stop until our voices are heard and reconsiderations are made this fall to play all fall sports.”Despite nixing indoor volleyball, the MPA gave schools the clearance to play the sport outdoors if they can do so safely. Mount Desert Island Athletic Director Bunky Dow expressed optimism in the MPA’s ability to provide a workable environment for a traditional indoor season early next year.“We have three courts right now that we can use for outdoor volleyball, so we can do something there,” Dow told The Ellsworth American. “For indoor, if you put it between the winter and spring seasons, the only thing you’re really competing against is fine arts. I think that’s something that could work out, and it’s good for our volleyball program.”The MDI Regional School System and Ellsworth School Department approved fall seasons at their respective board meetings Thursday and Friday. Dow and Ellsworth Athletic Director Josh Frost had recommended prior to the MPA’s announcement that their boards adopt whatever proposal was approved by the governing body.In late August, Consolidated School District 13 (Deer Isle-Stonington) announced it would not be holding soccer this fall and instead offer only golf and cross-country. Yet the CSD 13 Board reversed that decision Monday, one day after Superintendent Christian Elkington recommended the district offer the sport at the high school level.“We will do our best to schedule 8-10 games,” Elkington said in a memo to board members. “We hope to learn from our experiences with varsity soccer and what other schools find and work through this fall to better inform how we will, potentially, handle a future winter sports season.”The administrative response to the MPA announcement was much different in Sullivan, where the Regional School Unit 24 Board of Directors voted Monday to uphold its earlier decision canceling the fall season. The 6-3 vote means Sumner Memorial High School and the district’s four K-8 schools will not take part in athletics this fall.Games and meets this season will be limited to attendances of 100 people in accordance with Governor Mills’ executive order limiting gathering sizes. Players, coaches, volunteers, officials, trainers, media members and spectators will all count toward the 100-person limit.“I think a lot of schools are still not sure what they’re going to do about fans,” Dow said. “We’d like to have them, but if we can’t, we might be looking at live-streaming the events. It’s important for those people who might not be able to be there that they still have a way to watch.”Schools in counties that have been assigned “yellow” or “red” designations under the Maine Department of Education’s guidelines on a return to classroom learning may not hold practices or games. With the exception of York County (yellow), all counties in Maine are currently designated as “green.”For teams participating in approved sports, the season is scheduled to begin with tryouts and the first practices Monday, Sept. 14. The first countable games and meets may be held as early as the following Friday, Sept. 25.Update: This story has been updated to include announcements made by local school boards and comments from local administrators. Mike MandellMike Mandell is the sports editor at The Ellsworth American and Mount Desert Islander. He began working for The American in August 2016. You can reach him via email at Ellsworth runners compete in virtual Boston Marathon – September 16, 2020 Latest posts by Mike Mandell (see all) MPA approves golf, XC, field hockey, soccer; football, volleyball moved to spring – September 10, 2020last_img read more

Virat Kohli is positive despite losing to Chennai Super Kings

first_imgChennai: It was a start that Royal Challengers Bangalore (RCB) skipper Virat Kohli would like to forget as his team was thrashed by seven wickets by defending champions Chennai Super Kings (CSK) in the season opening game of the 12th edition of the Indian Premier League (IPL) here.But trying to remain positive despite the result on Saturday, Kohli said that it was good to get a loss like this out of the way early in the tournament. Having scored just 70 runs after losing the toss and batting first, Kohli’s men saw Chennai chase down the target in the 18th over of the innings.He revealed that the idea was to take the game as deep down as possible after a poor start with the bat.“No one wants to start like this, but it’s good to get a game like this out of the way – this early in the tournament. We spoke of trying to be in the game, taking it to the 18th over was nice to see.”While one would think it was a poor reading of the wicket that saw RCB play three frontline pacers in Umesh Yadav, Mohammed Siraj and Navdeep Saini, but Kohli backed the decision and said that the wicket looked much better than it played.“The batting wasn’t good, it wasn’t easy to bat on, looked much better surface though. I thought 140-150 would have been an ideal score, especially with dew expected later on. A scrappy start to the league, but I don’t think either team had control over it, the pitch was under the covers for 4 days, but we should have batted better, 110-120 would have been a fighting score,” he said.Also Read: SPORTS NEWSlast_img read more

Hardik Pandya Joins Hands With Nat Geo

first_imgNew Delhi: Indian all-rounder Hardik Pandya has joined hands with National Geographic’s ‘Choose The Planet’ initiative and has called upon people to reduce single-use plastic and make India free of the menace.On the occasion of 150th birth anniversary of Mahatma Gandhi, Pandya tweeted: “When it comes to the planet, we are all on one team. Planet or Plastic? I #ChooseThePlanet.”He also nominated his teammates – Rohit Sharma, Krunal Pandya and KL Rahul to take the pledge. (IANS) Also Read: Pakistan Cricketer Abdul Razzaq ‘I can Make Hardik Pandya One of The Best All-Rounders’Also Watch: Durga Puja 2019: Puja Preparations at Naba Bikas Sangha in Guwahlast_img read more