BAFFERT’S TALENTED CHARLATAN ATTEMPTING TO FOLLOW 2018 TRIPLE CROWN WINNER JUSTIFY AS HE MAKES SECOND START AT SANTA ANITA ON SATURDAYNO PUBLIC ADMISSION ALLOWED, FIRST POST TIME FOR EIGHT-RACE CARD IS AT 1 P.M.; WAGERING AVAILABLE AT TRACK’S 1/ST BET & XPRESSBET APPS ARCADIA, Calif. (March 12, 2020)–Although plenty of attention will be focused on Santa Anita’s seventh race Saturday, the Grade I Beholder Mile, the eyes of the racing world will also be riveted on the race just before it, a $57,000 allowance for 3-year-olds at one mile. Bob Baffert’s talented Charlatan, a 5 ¾ length first-out maiden winner on Feb. 16, will attempt to follow in the footsteps of Baffert’s 2018 Triple Crown winner Justify as he stretches out and tries to muscle his way onto the Kentucky Derby trail.The comparisons are unavoidable. Justify, a chestnut colt by Scat Daddy, was foaled in Kentucky on March 28, 2015, sold as a Keeneland September Yearling for $500,000, was unraced at two and was a first-out maiden winner with Drayden Van Dyke up on Feb. 18, 2018.Charlatan, a chestnut colt by Speightstown, was foaled in Kentucky on March 2, 2017, sold as a Keeneland September Yearling for $700,000, was unraced at two and broke his maiden two days earlier than Baffert’s 2018 superstar with you guessed it, Drayden Van Dyke up.From there, Baffert and Van Dyke are hoping history continues to repeat itself, as Charlatan, like Justify two years ago, will be stretching out in a one mile allowance Saturday and will be running over what could be an “off ” surface. (Justify was a 9 ½ length one mile allowance winner over a muddy track, getting the distance in 1:35.73).At this stage, one discernable difference in comparing the two horses at this moment in time is that Mike Smith replaced Van Dyke for Justify’s win, while Van Dyke has retained the mount on Charlatan.First post time for an eight-race card on Saturday is at 1 p.m. There will be no public admission, in accordance with recent health dictates issued by the state of California. Assigned post time for race six is at 3:35 p.m. PT.Wagering on all Santa Anita live racing is available via the track’s 1/ST BET and Xpressbet apps. For additional information on racing and wagering at Santa Anita Park, please visit santaanita.com or call (626) 574-RACE.
FC Barcelona’s Gerard Piqu, center, celebrates with his teammates after scoring during a Spanish Copa del Rey round of 32 second leg soccer match between FC Barcelona and Murcia at the Camp Nou stadium in Barcelona, Wednesday, Nov. 29, 2017. (AP Photo/Manu Fernandez)MADRID, Spain—Barcelona reached the last 16 of the Copa del Rey with a comfortable 5-0 win over Murcia on Wednesday, but Basque Country teams Real Sociedad and Athletic Bilbao were eliminated by third-division clubs.Atletico Madrid advanced after a 3-0 win against Elche to overcome a first-leg draw.ADVERTISEMENT Coco’s house rules on ‘Probinsyano’ set Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award It’s too early to present Duterte’s ‘legacy’ – Lacson Margot Robbie talks about filming ‘Bombshell’s’ disturbing sexual harassment scene OSG plea to revoke ABS-CBN franchise ‘a duplicitous move’ – Lacson Conte sent to stands as Chelsea beats Swansea Pique, who missed the Spanish league game against Valencia at the weekend, started the match at Camp Nou but was substituted right after scoring his 56th-minute goal.Barcelona is trying to become the first team to win four straight Copa del Rey titles since Athletic Bilbao in 1930-33.Sociedad stunnedTeenager Bojan Radulovic scored an 87th-minute goal that allowed third-division club Lleida to eliminate top-flight club Real Sociedad on away goals.Lleida won 3-2 after trailing by two goals at halftime at Anoeta Stadium. It had lost the first leg 1-0 at home.ADVERTISEMENT Jake says relationship with Shaina ‘goes beyond physical attraction’ Barcelona striker Paco Alcacer scored in the first half and Gerard Pique, Aleix Vidal, Denis Suarez and Jose Arnaiz each added goals after halftime to give the hosts an 8-0 aggregate win against the third-tier club.“We played with great attitude,” Barcelona coach Ernesto Valverde said. “You don’t want to go through any scares in these games, and the best way to do that is to play with good rhythm and dynamism.”FEATURED STORIESSPORTSRedemption is sweet for Ginebra, Scottie ThompsonSPORTSMayweather beats Pacquiao, Canelo for ‘Fighter of the Decade’SPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkBarcelona played without most of its regular starters, including Lionel Messi and Luis Suarez.Valverde had also rested the team’s top players in the 3-0 first-leg win last month. Jake says relationship with Shaina ‘goes beyond physical attraction’ Jo Koy: My brain always wants to think funny “This hurts,” Sociedad coach Eusebio Sacristan said. “We have to ask for the fans’ forgiveness. We are very disappointed.”Sociedad, seventh in the Spanish league, went ahead with goals by Diego Llorente and Juanmi, but the Catalan outsiders rallied with goals by Aitor Nunez and Manu Molina early in the second half. The 18-year-old Radulovic stunned Sociedad with a header near the end.“I’m speechless,” Radulovic said. “It’s my first goal with the first team, in a stadium like this, against a first-division club.”Bilbao oustedAthletic Bilbao was eliminated by Formentera after conceding a goal in the sixth minute of stoppage time at its San Mames Stadium, losing the two-leg series 2-1.“We know that this is a huge loss and that the fans are disappointed,” Athletic coach Jose Angel Ziganda said. “This is probably the worst moment I’ve had to go through as a coach.”Substitute Alvaro Muniz netted the winner with a header off a corner kick cross to stun the home crowd in Bilbao.“Tomorrow it will sink in what it means to beat Athletic in its stadium,” Formentera coach Jose Angel Garcia Sanjuan said.Atletico stays aliveFernando Torres scored a goal in each half as Atletico easily defeated third-division club Elche at the Wanda Metropolitano Stadium, advancing 4-1 on aggregate. View comments MOST READ Coco’s house rules on ‘Probinsyano’ set Kiss-and-tell matinee idol’s conquests: True stories or tall tales? LATEST STORIES The goals ended Torres’ scoring drought after 13 matches this season.Jose Gimenez also scored for Atletico, which has won three straight in all competitions.Sevilla advancesWissam Ben Yedder scored twice in the first six minutes to lead Sevilla to a 4-0 win over third-division club Cartagena, securing a spot in the last 16 with a 7-0 win on aggregate.Paulo Henrique Ganso added to the lead just before halftime and Joaquin sealed the victory in the second half.It was Sevilla’s first match without coach Eduardo “Toto” Berizzo, who underwent surgery to treat prostate cancer on Tuesday.Assistant coach Ernesto Marcucci is in charge until Berizzo returns.Las Palmas goes throughLas Palmas advanced 6-4 on aggregate after a 3-2 home loss to Deportivo La Coruna, but it lost striker Vitolo just before halftime because of a left leg injury. 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Don’t miss out on the latest news and information. View comments Steam emission over Taal’s main crater ‘steady’ for past 24 hours China population now over 1.4 billion as birthrate falls Sports Related Videospowered by AdSparcRead Next Jiro Manio arrested for stabbing man in Marikina Dave Chappelle donates P1 million to Taal relief operations LATEST STORIES But it was a whole different story for the Beermen in the additional five minutes, going scoreless in the first two and a half minutes as Rain or Shine raced to a 118-112 lead as it banked on Almazan’s cool free throw shooting to nab the victory.Rain or Shine improved to 4-1 to gain solo leadership early in the conference, while sending powerhouse San Miguel to its first 0-2 start in three seasons.Santos paced the Beermen with 29 points on 6-of-13 shooting from three, alongside nine rebounds, four assists and five blocks while Fajardo got 26 points and 11 rebounds in a foul-plagued outing.Marcio Lassiter also poured 18 points and five assists, while Christian Standhardinger had his best game to date with 17 points and 15 rebounds.The scores:RAIN OR SHINE 123 — Johnson 27, Almazan 25, Ahanmisi 16, Tiu 16, Norwood 15, Daquioag 7, Torres 5, Washington 5, Ponferada 4, Yap 3, Belga 0, Onwubere 0.SAN MIGUEL 119 — Santos 29, Fajardo 26, Lassiter 18, Standhardinger 17, Cabagnot 14, Gillenwater 11, Ganuelas-Rosser 2, Ross 2, Espinas 0.Quarters: 30-23, 49-63, 84-90, 112-112, 123-119. Winfrey details her decision to withdraw from Simmons film San Miguel also had to play all-Filipino for majority of the game after its import Troy Gillenwater got ejected after bumping referee Rey Yante at the 2:29 mark of the second quarter.The guards also made significant contributions for Rain or Shine.Chris Tiu collected 16 points on 3-of-6 shooting from three, three rebounds and six assists, Maverick Ahanmisi also had 16 points, six rebounds, four assists, and three steals, while Gabe Norwood had 15 points, eight rebounds, and five assists.Fighting back from 17-points down, 68-51 in the third quarter, the Elasto Painters had a chance to seal the game shut in the final 18.4 seconds, but Tiu uncharacteristically split from the line and kept the window open for the Beermen, 112-110.Alex Cabagnot then, swooped in for the layup to tie the game at 112 with 11.4 ticks remaining. San Miguel almost stole the win at the end of regulation after forcing a stop on a Gabe Norwood inbound, but Chris Ross missed a triple that paved way for OT.ADVERTISEMENT In fight vs corruption, Duterte now points to Ayala, MVP companies as ‘big fish’ Jury of 7 men, 5 women selected for Weinstein rape trial MOST READ Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew UST eyes PBA D-League stint ahead of UAAP “The effort of the players, they showed their character today,” said a jubilant ROS coach Caloy Garcia as Rain or Shine redeemed itself after dropping a 96-104 decision to Columbian Dyip last Wednesday.“It was a test of character for both teams, and luckily we were able to pull this win.”FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownElasto Painters import Reggie Johnson was also too much to handle for the Beermen, finishing with 27 points, 19 rebounds, four assists, and two blocks.Johnson’s presence down low was a big problem for San Miguel Beer after its MVP center June Mar Fajardo and lanky forward Arwind Santos fouled out in the crucial stages. Photo by Tristan Tamayo/INQUIRER.netANTIPOLO — Rain or Shine bounced back with a thrilling 121-115 overtime victory over defending champion San Miguel Beer in the 2018 PBA Commissioner’s Cup Sunday at Ynares Center here.Raymond Almazan carried Rain or Shine in the extra period, where he uncorked eight of his career-high-tying 25 points. He wound up with a double-double after hauling down 14 rebounds.ADVERTISEMENT Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Volcano watch: Island fissures steaming, lake water receding
… but President says may be an error by Venezuelan militaryThe Government of Guyana is preparing to engage the United Nations (UN) Secretary General Ban Ki-moonPresident David Grangerafter it received the preliminary report into an incident on Monday, where three mines officers attached to the Guyana Geology and Mines Commission, while patrolling in the Cuyuni River, came under heavy gunfire from members of the Venezuelan Army.Based on preliminary reports, on Monday, May 30, 2016, around 17:30h, the three officers were returning from a monitoring and inspection exercise at Arau in the Cuyuni River, when the chartered boat in which they were travelling came under attack by Venezuelan soldiers, approximately one mile up from the Eteringbang Police Station.“This matter will be brought to the attention of Secretary General of the United Nations in his capacity as Good Officer under the Geneva Agreement and members of the UN and its Security Council will also be notified,” a statement from Guyana’s Foreign Affairs Ministry on Wednesday stated.Also, the Foreign Affairs Ministry said it has dispatched a Note Verbale to the Venezuelan Foreign Affairs Ministry, conveying the Government of Guyana’s “grave concern” over this incident.The note also called on the Venezuelan Government to “desist from such provocative and dangerous actions on the Guyana border,” adding that such actions can only lead to a destabilisation of relations.Meanwhile, speaking to the Guyanese media on Wednesday afternoon, President David Granger explained that Guyana Defence Force Chief-of-Staff, Brigadier Mark Phillips is in contact with the Venezuelan General.He however noted that based on information, the incident may have been an error on the part of the Venezuelan military stationed at the border.“We have received information that there might have been some error on the part of the Venezuelan national Armed Forces and the matter is now being investigated and we are working towards a resolution of the controversy and we are trying to find out what occurred but I wish to assure you that the situation is not deteriorating and it is not going to be generating into any confrontation,” the President, a former Army General stated.He quickly dismissed suggestions that the incident was deliberate, since also during Guyana’s independence celebrations last year, there were acts of aggression from Venezuela.“What occurred on the 26th of May, 2015, was deliberate and the promulgation of that decree. As you know, after [Caribbean Community] Caricom Heads of Government (meeting) the decree was withdrawn under pressure from the Caribbean Community and another decree was issued. I do not see it as a continuation, I do not think the two incidents are linked and like I said, right now, it’s too soon to tell and I would like to await information from the Chief-of-Staff who is in touch with the Venezuelans,” the President noted.Relations between Guyana and Venezuela have been tense over the past few months after the Bolivarian Republic continues to lay claim to over two thirds of Guyana’s territory, even though an 1899 Arbitration panel awarded the disputed Essequibo region to Guyana.In February 1966, just before Guyana was granted independence, in Geneva, Switzerland, the Governments of British Guiana, the United Kingdom and Venezuela signed an agreement to resolve its contentions, but Venezuela has sporadically raised the controversy it created.The controversy was reignited by Venezuela when the Government of Guyana granted access to the US-based oil exploration company ExxonMobil, allowing it to drill for oil in the Stabroek block offshore Essequibo.The Venezuelan Government was peeved at this move and made direct contact with the oil company, urging it to discontinue its attempt to carry out drilling activities in the area. Saying it had no part in the territorial issue, the oil company went ahead with its drilling activity.President Maduro later issued a decree on May 26, 2015, which purported to ratify maritime sovereignty over waters within 200 miles including the entire Atlantic Ocean off the Essequibo Coast as well as part of Suriname’s maritime territory and an area which is under dispute with Colombia.Guyana has been seeking the UN’s help in resolving the issue and has sought a juridical settlement if the UN process fails.
Walton said Monday he woke up with the ankle feeling great. When he got on the floor at shootaround he couldn’t shake the pain. The Lakers have had to scale him back from rehab work to treatment sessions. “I’m able to do more and more stuff,” said Walton, who initially was expected to miss about a week. “I just can’t do the full-out running or the cutting yet. Until I can do that, I can’t play.” Meanwhile, Kwame Brown was to fly to Indianapolis after practice to get a second opinion on his injured left ankle, which he rolled Dec. 31. Center Chris Mihm also is on this trip and was working out on an elliptical machine Tuesday. Mihm was supposed to be out for the season after undergoing a second ankle surgery but could return if his rehab continues to be ahead of schedule. Two-man game: Jackson was asked about Kobe Bryant’s balancing act between taking over games and trusting his teammates. He did both in the fourth quarter Monday, scoring 11 points but also giving up the ball to Smush Parker for a key 3-pointer. Yet Walton was unable to practice Tuesday, and his availability is in question with the Lakers playing back-to-back games against the Pistons and Toronto Raptors. They will finish the trip Sunday at Cleveland. “He’s getting frustrated with the situation,” Lakers coach Phil Jackson said. “It’s longer than he ever thought it would be. It’s just difficult for him to sustain it when you’re on the road like this, and you’re trying to find a way to get out there and nothing seems to work right.” ATLANTA – Never would the Lakers have guessed when they left on this eight-game trip more than a week ago that they might arrive home with forward Luke Walton still struggling to return from a sprained right ankle. Walton suffered the injury Jan. 26 and has missed sixgames as a result. He hoped to return Monday against the Hawks. “We really think that if we distribute the ball at the right time in the game when the focus comes on him, there’s some easy shots that people have,” Jackson said. “If he trusts his teammates in those situations, we’re really a difficult team to stop.” email@example.com (818) 713-3610 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
1 Sadio Mane completed his £30m move to Liverpool on Tuesday Liverpool manager Jurgen Klopp tracked Sadio Mane for four years before finally managing to sign him.The 24-year-old became Liverpool’s third most expensive player when he completed a £30million move from Southampton.Klopp is delighted to have captured the Senegal international, who Press Association Sport understands has signed a five-year contract.“I have followed Sadio for a lot of years since his impressive performances in the Olympics in 2012, and then watched his development in Austria and in his time at Southampton,” the Reds boss told liverpoolfc.com.“Since I came here I have spoken to the staff a lot about him and have always felt he could be a very good signing for us.“He has a lot of quality, works hard and has a very good goalscoring record.“When I spoke to him I could tell that he was passionate about joining the club and playing for our fantastic fans.“I think they will be just as excited about seeing him put on a Liverpool shirt as I am.“It is great that we have managed to sign him so he can work with us from the first day of pre-season.”Klopp was a major influence on persuading Mane to leave the Saints, for whom he scored 25 goals in 75 appearances.The forward admits he did not have to think twice when Klopp asked him to join.“I spoke with him and I think he played a big role in me coming to Liverpool and I want to thank him for all the confidence,” the striker, who will wear the number 19 shirt, told LFCTV.“He said he wanted me to come and I didn’t try to ask myself questions as I was convinced Liverpool was the right club for me.“It is the right club, right coach and right moment to change.
ATHLETICS: Organisers of the hugely popular Gael-Force North Event have decided to revamp this year’s course.With many participants last year, expressing their dislike for the Kayak part of the course – organisers decided to re-evaluate the event. They’ve now created a new Duathlon course for participants and they believe that this year’s Gael-Force North Event will be the best one yet!If you’d like to participate in the event then sign up now. (See link below)Take the Bridle path for Gaelforce North – 25th June 2016Is the Kayak part of the course putting you off?? New Duathlon course this year! Sign up here http://bit.ly/1HfFYd9 ATHLETICS: NEW DUATHLON COURSE AT THIS YEAR’S GAELFORCE NORTH EVENT was last modified: March 9th, 2016 by Mark ForkerShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:duathlonGael-Force North EventSport
SAN JOSE — Joe Thornton’s one-punch altercation with Carolina Hurricanes goalie Petr Mrazek earlier this month — and his verbal jabs on the bench at Tom Wilson of the Washington Capitals a few days earlier — made the rounds on social media and no doubt lifted the spirits of his teammates.What’s been just as enjoyable from the Sharks perspective in recent days is seeing Thornton recapture some of his old playmaking form.Going into Tuesday’s game with the Arizona Coyotes, Thornton, playing with …
Medical experts have been powerless to stop the rise of antibiotic-resistant bacteria and are increasingly desperate to develop novel drugs. But a new study finds that smarter use of current antibiotics could offer a solution. Researchers were able to keep resistant bacteria from thriving by alternating antibiotics to specifically exploit the vulnerabilities that come along with resistance—a strategy that could extend the lifespan of existing drugs to continue fighting even the most persistent pathogens.The prevailing theory on how resistance develops posits that reckless antibiotic-prescribing practices drive the evolution of resistant microbes. Because bacterial genes mutate at high frequencies, any bacterial population will have many individual microbes carrying different mutations. By chance, one or several may fight off an antibiotic, and those resistant variants will survive to proliferate.Based on this notion, doctors have long tried to alternate antibiotic drugs to prevent resistance. By limiting exposure to any one drug, they hope to reduce the chance that a single type of resistant bacteria predominates. Once the antibiotic is removed, they expect the nonresistant bacteria to multiply and outcompete the resistant variants, which then naturally die out. This practice assumes, however, that resistant bacteria are less “fit” than other bacteria. In practice, the results of alternating drugs have been mixed, and resistant bacteria often survive.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In the new research, systems biologists Lejla Imamovic and Morten Sommer of the Technical University of Denmark in Lyngby used Escherichia coli to explore how bacteria change when they become resistant to a drug. They found that when E. coli gains resistance to one antibiotic, it also becomes more sensitive others—a phenomenon they call “collateral sensitivity.”For example, bacteria often become resistant to the antibiotic tetracycline by gaining an efflux pump—a membrane protein that pumps antibiotics and other compounds out of the cell. But the pump also enables compounds to flow in, making the bacteria more sensitive to other antibiotics. Using this knowledge, one could introduce a second antibiotic that flows in via these efflux pumps to kill the resistant variants.By applying what the authors dub “collateral sensitivity cycling,” doctors could kill resistant bacteria by switching to an antibiotic they have become more vulnerable to because of their resistance to the first drug, Sommer explains. The idea of cycling antibiotics dates back to the 1950s, he says, but fell out of favor after the boom in drug development.To test the approach, Imamovic and Sommer exposed a lab strain of E. coli to increasing doses of an antibiotic until resistant variants emerged. They then exposed the variants to 23 different antibiotics and profiled their responses: Did they become more or less resistant to each of the 23 drugs? The researchers repeated the experiment with two E.coli strains taken from infected patients. Then they plugged this data into a computer program and identified more than 200 possible drug combinations that doctors could use to achieve collateral sensitivity and wipe out resistant variants. These drugs could be prescribed in cycles as either double, triple, or quadruple treatments, the authors report online today in Science Translational Medicine.The idea seems so simple, Sommer says, that one reviewer of the paper remarked, “I can’t believe that no-one has done this before.” But Sommer had spent hours searching the literature but had turned up nothing—not a single study that used the idea of collateral sensitivity to choose antibiotics. “Many people have advocated switching drugs,” says Robert Beardmore, a bioscience mathematician at the University of Exeter in the United Kingdom. “But this shows that you can’t just make any old switches. You can take a path of choices to form something like an entire treatment that selects against resistance.”There is one bit of caution: The researchers have done the tests only in vitro and used only E. coli, Beardmore says. “The acid test will be when these ideas are implemented in vivo.”
Lacson backs proposal to elect president and vice president in tandem “It was a big day for us,” coach Felix Sanchez said. “We achieved something that is history for us so I just want to congratulate everyone.”In Abu Dhabi, midfielder Abdelaziz Hatim hit the only goal for Qatar with a left-foot shot from outside the area in the 78th minute. South Korea’s best chance came a minute earlier when Kim Jin-su hit the post from a free kick.In Al Ain, the UAE avenged its 2015 semifinal loss to Australia. Ali Ahmed Mabkhout pounced on a defensive blunder to claim his fourth goal of the tournament and spark wild celebrations at the Hazza Bin Zayed Stadium.“We said from the beginning that we don’t have the ambition to play attractive football,” said Mabkhout. “If it comes with a win, that’s okay. The important thing for us is to get results. The other things aren’t important.”ADVERTISEMENT Qatar, the 2022 World Cup host nation, reached the last four of Asia’s continental showpiece for the first time by beating two-time champion South Korea 1-0. The UAE defeated title-holder Australia by the same score to set up a meeting with Qatar in Abu Dhabi on Tuesday.The other semifinal is on Monday in Al Ain with Japan taking on Iran.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsSouth Korea’s exit is good news for Tottenham as forward Son Heung-min can rejoin his injury-hit English Premier League club earlier than expected.Qatar is the surprise package of the tournament, scoring 12 goals without conceding and notching five straight wins. Sports Related Videospowered by AdSparcRead Next Private companies step in to help SEA Games hosting United Arab Emirates’ forward Ali Mabkhout, celebrates his goal, the opening goal, during the AFC Asian Cup quarterfinal soccer match between United Arab Emirates and Australia at Hazza Bin Zayed Stadium in Al Ain, United Arab Emirates, Friday, Jan. 25, 2019. (AP Photo/Hassan Ammar)ABU DHABI, United Arab Emirates — Qatar and the United Arab Emirates will meet in a politically-charged semifinal at the Asian Cup after they knocked out the two favorites Friday.Since June 2017, the UAE has been part of a quartet of nations leading an economic and diplomatic boycott of Qatar. The standoff has impacted Qatar’s logistics at the Asian Cup in the UAE but not its performances on the field.ADVERTISEMENT LATEST STORIES US judge bars Trump’s health insurance rule for immigrants ‘We are too hospitable,’ says Sotto amid SEA Games woes Don’t miss out on the latest news and information. Oil plant explodes in Pampanga town PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss MOST READ View comments SEA Games hosting troubles anger Duterte Oil plant explodes in Pampanga town Ateneo survives San Beda, advances to PCCL Finals Grace Poe files bill to protect govt teachers from malicious accusations