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Medical experts have been powerless to stop the rise of antibiotic-resistant bacteria and are increasingly desperate to develop novel drugs. But a new study finds that smarter use of current antibiotics could offer a solution. Researchers were able to keep resistant bacteria from thriving by alternating antibiotics to specifically exploit the vulnerabilities that come along with resistance—a strategy that could extend the lifespan of existing drugs to continue fighting even the most persistent pathogens.The prevailing theory on how resistance develops posits that reckless antibiotic-prescribing practices drive the evolution of resistant microbes. Because bacterial genes mutate at high frequencies, any bacterial population will have many individual microbes carrying different mutations. By chance, one or several may fight off an antibiotic, and those resistant variants will survive to proliferate.Based on this notion, doctors have long tried to alternate antibiotic drugs to prevent resistance. By limiting exposure to any one drug, they hope to reduce the chance that a single type of resistant bacteria predominates. Once the antibiotic is removed, they expect the nonresistant bacteria to multiply and outcompete the resistant variants, which then naturally die out. This practice assumes, however, that resistant bacteria are less “fit” than other bacteria. In practice, the results of alternating drugs have been mixed, and resistant bacteria often survive.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In the new research, systems biologists Lejla Imamovic and Morten Sommer of the Technical University of Denmark in Lyngby used Escherichia coli to explore how bacteria change when they become resistant to a drug. They found that when E. coli gains resistance to one antibiotic, it also becomes more sensitive others—a phenomenon they call “collateral sensitivity.”For example, bacteria often become resistant to the antibiotic tetracycline by gaining an efflux pump—a membrane protein that pumps antibiotics and other compounds out of the cell. But the pump also enables compounds to flow in, making the bacteria more sensitive to other antibiotics. Using this knowledge, one could introduce a second antibiotic that flows in via these efflux pumps to kill the resistant variants.By applying what the authors dub “collateral sensitivity cycling,” doctors could kill resistant bacteria by switching to an antibiotic they have become more vulnerable to because of their resistance to the first drug, Sommer explains. The idea of cycling antibiotics dates back to the 1950s, he says, but fell out of favor after the boom in drug development.To test the approach, Imamovic and Sommer exposed a lab strain of E. coli to increasing doses of an antibiotic until resistant variants emerged. They then exposed the variants to 23 different antibiotics and profiled their responses: Did they become more or less resistant to each of the 23 drugs? The researchers repeated the experiment with two E.coli strains taken from infected patients. Then they plugged this data into a computer program and identified more than 200 possible drug combinations that doctors could use to achieve collateral sensitivity and wipe out resistant variants. These drugs could be prescribed in cycles as either double, triple, or quadruple treatments, the authors report online today in Science Translational Medicine.The idea seems so simple, Sommer says, that one reviewer of the paper remarked, “I can’t believe that no-one has done this before.” But Sommer had spent hours searching the literature but had turned up nothing—not a single study that used the idea of collateral sensitivity to choose antibiotics. “Many people have advocated switching drugs,” says Robert Beardmore, a bioscience mathematician at the University of Exeter in the United Kingdom. “But this shows that you can’t just make any old switches. You can take a path of choices to form something like an entire treatment that selects against resistance.”There is one bit of caution: The researchers have done the tests only in vitro and used only E. coli, Beardmore says. “The acid test will be when these ideas are implemented in vivo.”
Lacson backs proposal to elect president and vice president in tandem “It was a big day for us,” coach Felix Sanchez said. “We achieved something that is history for us so I just want to congratulate everyone.”In Abu Dhabi, midfielder Abdelaziz Hatim hit the only goal for Qatar with a left-foot shot from outside the area in the 78th minute. South Korea’s best chance came a minute earlier when Kim Jin-su hit the post from a free kick.In Al Ain, the UAE avenged its 2015 semifinal loss to Australia. Ali Ahmed Mabkhout pounced on a defensive blunder to claim his fourth goal of the tournament and spark wild celebrations at the Hazza Bin Zayed Stadium.“We said from the beginning that we don’t have the ambition to play attractive football,” said Mabkhout. “If it comes with a win, that’s okay. The important thing for us is to get results. The other things aren’t important.”ADVERTISEMENT Qatar, the 2022 World Cup host nation, reached the last four of Asia’s continental showpiece for the first time by beating two-time champion South Korea 1-0. The UAE defeated title-holder Australia by the same score to set up a meeting with Qatar in Abu Dhabi on Tuesday.The other semifinal is on Monday in Al Ain with Japan taking on Iran.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsSouth Korea’s exit is good news for Tottenham as forward Son Heung-min can rejoin his injury-hit English Premier League club earlier than expected.Qatar is the surprise package of the tournament, scoring 12 goals without conceding and notching five straight wins. Sports Related Videospowered by AdSparcRead Next Private companies step in to help SEA Games hosting United Arab Emirates’ forward Ali Mabkhout, celebrates his goal, the opening goal, during the AFC Asian Cup quarterfinal soccer match between United Arab Emirates and Australia at Hazza Bin Zayed Stadium in Al Ain, United Arab Emirates, Friday, Jan. 25, 2019. (AP Photo/Hassan Ammar)ABU DHABI, United Arab Emirates — Qatar and the United Arab Emirates will meet in a politically-charged semifinal at the Asian Cup after they knocked out the two favorites Friday.Since June 2017, the UAE has been part of a quartet of nations leading an economic and diplomatic boycott of Qatar. The standoff has impacted Qatar’s logistics at the Asian Cup in the UAE but not its performances on the field.ADVERTISEMENT LATEST STORIES US judge bars Trump’s health insurance rule for immigrants ‘We are too hospitable,’ says Sotto amid SEA Games woes Don’t miss out on the latest news and information. Oil plant explodes in Pampanga town PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss MOST READ View comments SEA Games hosting troubles anger Duterte Oil plant explodes in Pampanga town Ateneo survives San Beda, advances to PCCL Finals Grace Poe files bill to protect govt teachers from malicious accusations
AdvertisementKSI vs Logan Paul was billed as the biggest event on the internet, as the two youtube superstars from the United Kingdom and the United States went toe to toe with each other exchanging heavy leathers in front of a sold-out crowd of 21,000 fans at the Manchester Arena in London.The fight took place at the early hours of the morning as per IST and with millions of people watching the fight online through different means. This was truly a historic event for YouTubers and many also compared it to Conor McGregor vs Floyd Mayweather of YouTube world and both guys collectively had over 37 Million subscribers.The fight, however, wasn’t free and came with a price tag of 10 USD or 7.5 GBP or ₹668.00. Although the price wasn’t insanely high like Mayweather vs McGregor which cost around $100, still many people were found watching the fights via illegal streaming channels.Although the early estimates indicated that the fight sold around 800,000 PPV, but KSI speaking to talkSport revealed that fight sold over a Million PPV buys – roughly equating Conor McGregor vs Chad Mendes buyrate at UFC 189.“It’s over a mil,” KSI told Hawksbee and Jacobs on Tuesday.“Over 950,000 on YouTube and then 100,000+ on another website [which was also used to distribute the fight].”He also tossed away the rumors of both making upwards of £40m.“It’s definitely not right, that’s ridiculous that amount,” he said with a chuckle.“I mean obviously it’s a high amount, but it’s nowhere near £40m.”“Ten years ago when I started this whole YouTube thing I never thought I’d be in a ring, especially at Manchester Arena in front of thousands there live and millions around the world.“If someone had told me that ten years ago, I’d have told them they’re smoking something.”This 1 Million figure dwarfs major PPV Boxing/MMA events; last year not a single UFC PPV was able to cross the 1 Million mark and in fact, up until the this year’s last UFC PPV which took place earlier this month UFC 227 had also failed to crack a million buys.Even major Boxing PPV’s which took place in UK including Haye vs Bellew failed to cross the million buys mark.Also Read-Logan Paul and KSI battle to a ‘MAJORITY DRAW’ Advertisement
LOS ANGELES, CA — Although the Los Angeles Kings and the New York Rangers have played 41 combined postseason games over the previous six weeks, they still have ample energy for the big finale to their epic playoff chase.“No, you don’t get tired right now,” said Kings forward Marian Gaborik, the former 40-goal scorer for the Rangers. “All you think about is winning the Stanley Cup.”When they meet at Staples Center on Wednesday night to begin the first New York-L.A. Cup final in NHL history, the Rangers and Kings are prepared for one more exhausting series in a spring filled with two-week sagas, nail-biting finishes and Game 7 heroics.No team in NHL history had made it to the Stanley Cup finals after going seven games in each of the first two rounds — until New York and Los Angeles both did it this spring. The Kings even went one longer, playing the maximum 21 games.Yet neither team will be satisfied without one more achievement. The Rangers haven’t won the Stanley Cup since 1994, while the Kings are just two years removed from their only NHL championship. Two franchises long familiar with losing have the chance to raise the Cup again, and the players already felt the energy building when they went through practices Tuesday.“It’s definitely been a grind, but that’s why you play hockey,” Kings forward Jeff Carter said. “We know what we went through to get here, and we’re willing to go through a little more.”Five things to watch when the Kings host Game 1 of the Stanley Cup finals for the first time in franchise history:PLAYING FAVORITES: Although Los Angeles won just one more regular-season game than New York, most hockey observers think the Kings are strong favorites after they survived three playoff rounds in the superior Western Conference. Neither team is listening: The Kings aren’t interested in prognostication, and the Rangers relish the pressure-free role of an underdog. “It doesn’t matter about public opinion, media opinion,” New York’s Martin St. Louis said. “We’re still here, and we know we have a chance.”GOOD TO GO: Kings goalie Jonathan Quick said he’s fine after leaving practice a bit early Tuesday when he took a shot off his collarbone. Although the Kings are the NHL’s highest-scoring playoff team, defense-minded Los Angeles needs its franchise goalie in top form. Quick has won three straight Game 7s this spring, even if his statistics aren’t as impressive as they were in his Conn Smythe-winning season in 2012. The Rangers can’t expect Quick to help them out the way he did in New York’s only previous trip here in October, when he knocked Ryan McDonagh’s long clearing attempt into his own net during a 3-1 loss.NO CAPTAIN, MY CAPTAIN: You won’t see a “C” on a blue shirt this series. If the Rangers win the Stanley Cup, they don’t have a captain to raise it after trading Ryan Callahan in March. That role is being played unofficially by Brad Richards, a healthy scratch in last season’s playoffs and a potential salary-cap casualty this summer. But the 2004 Conn Smythe winner, who flirted heavily with the Kings in free agency in 2011, is back in form this season. The Rangers likely need his resurgent offense to win that Cup.DEWEY THE GREAT: Even after strong offensive efforts by Marian Gaborik, Anze Kopitar and Jeff Carter, the Kings believe their most dynamic playoff performer has been Drew Doughty. The inexhaustible defenseman is looking to add a second Stanley Cup title to his two Olympic gold medals, and he’s the current favorite for the Conn Smythe Trophy as the playoff MVP. Casual hockey fans who might not understand Doughty’s two-way brilliance should be in for a treat.SECONDHAND FAMILIARITY: Although the two teams haven’t met in six months, Rangers coach Alain Vigneault led the Vancouver Canucks against Los Angeles for seven years, including two of the previous four postseasons. He knows all about Kings coach Darryl Sutter’s defense-minded system and Los Angeles’ hard-hitting style. “It’s a team that obviously has grown through the years. It has a real good balance. That’s why they’re getting another chance to compete for the Cup.”TweetPinShare0 Shares
The Central Board of Secondary Education (CBSE) has recently revamped its norms for granting affiliation to schools.The affiliation bye-laws of the CBSE have been completely revamped to ensure speed, transparency, hassle-free procedures and ease of doing business with the board, said Union HRD Minister Prakash Javadekar.Here’s what Prakash Javadekar said:The new #CBSE affiliation byelaws denote a major shift from the highly complex procedures followed earlier, to a simplified system based on preventing duplication of processes. @cbseindia29 @HRDMinistry https://t.co/L3Ti0UQs4KPrakash Javadekar (@PrakashJavdekar) October 18, 2018″At present, for issuing recognition under the RTE Act and the NOC, the state education administration verifies various certificates to be obtained from local bodies, revenue and cooperative departments,” he said.”CBSE re-verifies them after the applications are received and hence the process becomes long drawn,” Javadekar added.Therefore, to prevent this duplication, schools will now be required to submit only two documents at the time of applying for affiliation, instead of 12-14 documents being submitted earlier.CBSE to open 8,000 new schools:Moreover, the board has reportedly cleared around 8,000 pending applications for affiliation, some of them dating back to 2007.According to a TOI report, in order to reduce the paperwork, the CBSE has brought down the requirement of documents from schools to just two while making it mandatory that all applications are disposed of in the same year. Earlier, 14 documents were required at the time of application to seek CBSE affiliation.School to disclose their fee structure:Further, the new provisions mandate schools to make full disclosure of fee structure and prohibit them from levying any hidden charges.advertisement”The board will now not revisit any of the aspects vetted by the state during its inspection and the delay due to scrutiny and non-compliance of deficiencies in these documents shall be drastically curtailed. Inspection of schools by the CBSE will now be outcome-based and more academic and quality-oriented,” Javadekar said in a recent PTI report.CBSE: Total number of schoolsAround 20,783 schools are affiliated to the CBSE across the country and abroad, with over 1.9 crore students and more than 10 lakh teachers. The affiliation bye-laws were formulated in the year 1998 and were last modified in 2012.Moreover, the HRD minister said, “The inspection by the CBSE will focus on academic excellence and progress of students over time, innovations and quality of pedagogy, capacity of teachers and teacher training, inclusive practices in school, quality of co-scholastic activities, whether the curricular load is as per norms and whether there is adequate emphasis on sports.”According to the new norms, the pendency of the applications will also be dealt with seriously and the applications will henceforth be disposed of in the same year, and the entire process will be online.Mandatory teacher training:The new affiliation bye-laws also lay thrust on achieving academic excellence through mandatory teacher training. Even the Principals and Vice Principals of every school are expected to undergo two days of mandatory training on an annual basis.Read: CBSE Class 10, Class 12 Board Exam 2019: LOC submission begins @ cbse.nic.in, check details hereRead: CBSE exams 2019: New passing criteria for CBSE Class 10 students, check full details here
About the authorPaul VegasShare the loveHave your say Man Utd U21 coach Wood hails Chong attitude for Lincoln winby Paul Vegas22 days agoSend to a friendShare the loveManchester United U21 coach Neil Wood has praised the attitude of Tahith Chong.The winger turned out for the EFL Trophy win over Lincoln City.Wood explained what the 19-year-old brings to his team.”I think it was good for him to be out there. He needed some game time and he did really well for the goal, got in between the lines and drove at the guy and went and had a good hand in the first goal,” Wood said.”He’s got great experience and he talks to the lads a lot on the pitch so we’re happy to have him with us.”
When opening its newest location in New Orleans, ACE Hotel wanted to collaborate with a local brand on a signature uniform for its staff. They quickly turned to heritage menswear brand Haspel, whose had its finger on the pulse of the city since its founding in 1909.The two creative forces came together to develop the look for the staff and landed on a twist on the classic seersucker suit, which Haspel first developed and popularized in New Orleans over one hundred years ago. The suit offers the ACE staff a contemporary look that also gives stylish nods to the past.“Haspel is very much a part of New Orleans’ style, past and present. Haspel was a natural partner for them. I had always admired the ACE hotel and how they have brought fresh perspective to hospitality,” starts designer Sam Shipley.“We’re known for inventing and popularizing the seersucker suit so doing a version of that for the hotel staff felt like a natural way to go.”Related: Haspel debuts spring/summer 2016 lookbookWhile the classic seersucker suit typically comes in a tailored slim fit, in either a white or light blue puckered cotton fabric, this updated spin sees Haspel playing with modern silhouettes and darker colors.“We have a great fitting suit in the collection already, but I wanted to develop a new shape—one that felt a bit younger and more relaxed,” states Shipley.“We ended up creating a black and navy seersucker suit with a very light jacket (almost like a shirt) and a tapered pant that has a slightly dropped crotch.”The effect is an easy to wear outfit that can be worn as a single suit or in separates. It’s casual, yet fashion-foward, and its light construction makes it the perfect ensemble for summer.Though the suit was designed with hotel staff in mind, ACE is also selling both the sport coat and the pleated trouser to the public through its website. Celebrating 110 Years of Seersucker: Happy Birthday to the Perfect Summer Suit The McMenamins Effect: How 2 Brothers Helped Start Beervana Getting to Know the Lithuanian Beer Scene Kentucky Breweries are Plowing Ahead on the Bourbon Trail Editors’ Recommendations Helpful Wine Terminology So You Sound Like You Know What You’re Talking About
Mexico’s Ambassador to Jamaica, His Excellency Juan José González Mijares, made the announcement at a reception to commemorate the 208th Anniversary of the Independence of Mexico, held at his residence in Cherry Gardens, St. Andrew, on Friday (September 14). A ‘Mexico Chair’ will be established at the University of the West Indies (UWI), Mona, in October 2018 as part of efforts to increase research collaboration and strengthen relations between higher-education institutions in Mexico and the university. Story Highlights A ‘Mexico Chair’ will be established at the University of the West Indies (UWI), Mona, in October 2018 as part of efforts to increase research collaboration and strengthen relations between higher-education institutions in Mexico and the university.Mexico’s Ambassador to Jamaica, His Excellency Juan José González Mijares, made the announcement at a reception to commemorate the 208th Anniversary of the Independence of Mexico, held at his residence in Cherry Gardens, St. Andrew, on Friday (September 14).The initiative was made possible through a Memorandum of Understanding (MOU) signed between the Mexican Foreign Ministry and UWI during the VIII Meeting of the Mexico-Jamaica Binational Commission in Mexico City on May 18, 2016.Ambassador González Mijares said that the honorary position of ‘Mexico Chair’ at UWI will enhance knowledge about Mexico within the Jamaican academic community.Lecturer and researcher at the Autonomous University of Baja California Sur, Dr. Rubén Olachea, has been selected as the first Mexico Chair. He will deliver classes in the Department of History at UWI, Mona, for a period of six weeks, from October 1 to November 9, within the framework of the MOU.Meanwhile, Jamaica is expected to host the IX Meeting of the Mexico-Jamaica Binational Commission scheduled to take place in early 2019. At this meeting, the Bilateral Cooperation Programme for 2019 will be reviewed and decisions taken on the commencement of projects.Some areas of collaboration to be discussed include climate change and resilience, the teaching of Spanish and the evaluation of social policies.The reception was attended by Minister of State for Foreign Affairs and Foreign Trade, Senator Pearnel Charles Jr., and other officials from the Ministry; members of the diplomatic corps; and senior government members.
zoom Representatives of China’s Qingdao Port Group signed a Memorandum of Understanding (MOU) with APM Terminals executives in The Hague for the APM Terminals Vado, Italy port project. The MOU will create a new joint venture to invest in and work with other potential partners. Terms and investment amount were not disclosed.APM Terminals Vado is a new terminal in northern Italy, which when opened in January 2018 is expected to be able to handle both containerized and liquid bulk cargoes – and integrated operationally with the existing 275,000 annual TEU capacity Vado Reefer Terminal facility, which was acquired by APM Terminals in August 2015.The Italian government is providing EUR 300 million for civil works for the project.APM Terminals is investing EUR 150 million in the new terminal which will create 450 new jobs when operations commence.In 2014, the ports of northern Italy’s Liguria range, including La Spezia, Genoa and Savona/Vado, handled a combined 3.5 million TEUs, representing an increase of approximately 6% compared with the previous year.The Port of Qingdao, located in the Shandong Province on the Yellow Sea, is one of northern China’s major ports. Qingdao is the 7th-busiest container port in the world, and the 5th-busiest in mainland China, with throughput of 16.6 million TEUs in 2014.APM Terminals is a minority shareholder in the Qingdao Qianwan Container Terminal (QQCT). QQCT has holdings in Qingdao Qianwan United Container Terminal and Qingdao New Qianwan Terminal.
Washington DC: Amazon.com Inc founder Jeff Bezos’ divorce from his wife of 25 years, MacKenzie Bezos, was finalised by a Seattle-area judge on Friday, paving the way for her to receive $38.3 billion worth of Amazon stock, Bloomberg reported. In April, Amazon, the world’s biggest online retailer, said in a filing that 4 per cent of its outstanding stock or 19.7 million shares would be registered in MacKenzie Bezos’ name after court approval of the divorce. Also Read – Maruti cuts production for 8th straight month in SepThe couple announced their plan to divorce in a joint Twitter statement in January, causing some to worry that Jeff Bezos could wind up with reduced Amazon voting power or that he or MacKenzie would liquidate large position. He retains a 12 per cent stake worth $114.8 billion and remains the world’s richest person, Bloomberg said. MacKenzie Bezos has said she would give him voting control of her shares. MacKenzie in May pledged to give half her fortune to charity to join the “Giving Pledge,” a campaign announced by billionaire Warren Buffett and Microsoft Corp co-founder Bill Gates in 2010.
Chris MacIntyreAPTN NewsThe Taku River Tlingit First Nation is hoping to expand its hydroelectric power station and to share the clean energy with others living in the Yukon.Peter Kirby, a member of the community and CEO of the Tlingit Homeland Energy Ltd., says he hopes to expand the power plant from providing power to his community to selling clean energy to the Yukon through Yukon Energy.“When we built this project we thought, there’s more energy in this creek,” he said. “We know the Yukon area well, we know the potential for projects in the Yukon region, and we know this project is exceptional to meet the needs of the Yukon.“We are ready, willing and able to have a conversation with supporters of the project and the potential customer Yukon on what that would mean in terms of energy purchase agreement and we hope to be there in the next few months.”(Constructed in 2009, the Atlin hydroelectric power station has been providing the community with clean energy. This station currently has an installed capacity of 2.1 Mega Watts)The hydroelectric station currently has an installed capacity of 2.1 mega watts of power.The community peaks at 1.4 mega watts with the remaining power being stored in a load bank.If the expansion plan gets the greenlight, the installed capacity would grow to 8.5 mega watts.Andrew Hall, president of Yukon Energy says he’s also optimistic about the project.He says that hydroelectric power is better long term but states that there are many hurdles to work through before negotiations can start.“There’s the technical feasibility. What does it take to bring that amount of power up to the Yukon, and up to Whitehorse? What kind of transmission lines do we need?“So there’s the technical piece and then there’s the financial. Do the numbers make sense?,” he said.Even with all the hurdles ahead, Kirby said he’s ready to do the work that needs to be done and remains proud of where the project started and where it could go.“I’m very proud of the work that we did in this community, our whole community,” said Kirby.“I’m very proud of what’s happened in our community since then.”firstname.lastname@example.org
KolkataL Those not aware of the struggles of Prime Minister Narendra Modi and BJP president Amit Shah have tried to create “fabricated” stories that the cadre-based party has become an individual-centric organisation, Union minister Muktar Abbas Naqvi said. Denying claims that a sense of fear prevails in the BJP, he said stories of no other senior leader apart from Modi and Shah are allowed to speak their mind are “fabricated”. Modi has been the biggest victim of “political intolerance” and a “few incidents by fringe elements” cannot be branded as intolerance against minorities, the senior BJP leader and Union minister for minority affairs told PTI in an interview. “Narendra Modi and Shah are both ground-level workers.They started their political journey as village and local level (mandal) workers. “Those who don’t know Amit Shah and Modiji (and their struggles) make such comments. They create such false and fabricated stories,” Naqvi said when asked whether a cadre-based party like the BJP has turned into a party of Modi and Shah. When asked if a sense of fear prevails in the BJP as no other leader apart from Modi and Shah are allowed to speak their mind, Naqvi said these are “fabricated stories” created by those who don’t know the prime minister and the party chief. Exuding confidence that the BJP will win more seats than 2014, Naqvi said Modi due to his good governance in the last five years has become “a very credible brand of development, good governance and stability”. “The last (general) election took place in the name of Narendra Modi, this time election is taking place on the basis of the work done by Narendra Modi. For the sake of betterment of the country, we need Narendra Modi’s government,” he said. Refuting claims that minorities are living under fear, threat and intimidation, the Union minister said that “a wrong perception was deliberately created”. “We followed the agenda of development for all without discrimination. In the last five years, not a single major communal riot has taken place in the country. “In the last five years, no major terrorist attack took place in our country, except for a few incidents in Kashmir where security forces have taken stern action,” Naqvi said. He claimed that earlier, during Congress’s rule, every 15 days there used to be a terrorist attack in India and apart from innocents being killed in these attacks, a large number of Muslim youths used to get arrested and branded as terrorists in the aftermath of these incidents. “Such incidents have never taken place in the last five years (of the Modi government),” the BJP leader said. On incidents of lynching, Naqvi said though there has been development without discrimination, “some fringe and criminal elements have tried to disrupt the agenda of development”. “Under Modiji’s rule we have not allowed such destructive agendas to get prominence, and those involved in such criminal activity, we had taken action against them,” he said. Commenting on allegations that the BJP is creating an atmosphere of intolerance, Naqvi said that “agreement and disagreements” are part of the democratic process, but, added that, Modi has been the biggest victim of political intolerance. “Modi is the biggest sufferer of political intolerance. In the last five years, the returning of awards campaign and many such campaigns are only examples of political intolerance. “Even things which were not even said by Modi or done by the BJP are termed as their statements. Neither he nor the BJP has ever said that if someone doesn’t agree with our views then he or she is anti-national,” he said. No government has ever faced so much of negativity that Modi and the present government had to face, Naqvi said, adding that despite negative campaigns, the Modi government has performed, reformed and transformed the nation. “In every democratic system agreement and disagreements are both sides of the same coin. This perception of intolerance against us is completely wrong,” he said. Last month veteran BJP leader L K Advani in a blog had said his party has never regarded those who disagreed with it politically as “anti-national” or “enemies” but only as adversaries. His comments came at a time when the BJP under Prime Minister Modi and Shah have made the issue of national security a key plank for the general elections and have often accused its political rivals of speaking the language of India’s enemies like Pakistan. Listing out achievements of the BJP government, Naqvi said the present dispensation has followed the policy of “development for all” and has been able to control inflation, price rise, corruption. It has brought back the economy on track, he said. Commenting on the violence during the Lok Sabha polls in West Bengal, he said the state administration is not supporting the Election Commission in conducting free and fair polls. “Goons supported by the TMC are influencing elections in Bengal. Despite daylight killings of opposition workers, not a single culprit is being arrested.The TMC is desperate as it has sensed defeat,” he said. In a first in the country, campaigning for nine Lok Sabha seats in Bengal going to polls in the last phase came to an end at 10 pm Thursday, 20 hours before the scheduled time, in the wake of violence between BJP and TMC workers in Kolkata during Shah’s roadshow on May 14.
Fez- The news has been shared by many Moroccans since it was first published by Moroccan news portal Hespress. Zouhair Benouahi, a Moroccan player who plays in Azerbaijan’s football league, said he was deprived of playing with the national team of football (soccer), because he once played against an Israeli team.The news might sound unbelievable, but this is what, Rachid Taoussi, the coach of Morocco’s national team allegedly told the player: “a player who plays in Israel can’t even dream of playing with the national team as long as I am the coach.” The player added that although Taoussi expressed his satisfaction of the player’s performance, he opposed his integration into the Moroccan team, on the grounds that he had played against an Israeli team during the first round of the Europa League. Faced with the impossibility of playing for Morocco, the player said he had no other choice than obtaining the Azerbaijani citizenship in order to play for its national team. © Morocco World News. All Rights Reserved. This material may not be published, rewritten or or redistribute
Mr. Somavia ran unopposed to continue his stint as the ninth Director-General in the Geneva-based agency’s 89-year history, and formally begins his new five-year term in March 2009. He assumed office as ILO chief in early 1999.During the past decade, the Chilean has led the promotion of the ILO’s Decent Work Agenda, and overseen the implementation of the Organization’s Declaration on Fundamental Principles and Rights at Work, which was adopted in 1998.The Organization has also seen a huge increase in the number of ratifications of ILO labour standards during his tenure, as well as its own adoption of a landmark Declaration on Social Justice for a Fair Globalization, in June of this year.“We stand today at a significant moment in this Organization’s history,” said Mr. Somavia. “Unemployment is rising. The crisis continues to batter economies and individuals across the world. The number of working poor is increasing. And there is a growing chorus of concern over the balance, fairness and sustainability of the current model of globalization.” 18 November 2008Juan Somavia was elected to a third term as Director-General of the United Nations International Labour Organization (ILO) today as he pledged to work to ensure social justice amid a growing series of challenges in the global economy.
Catch documentation schemes (CDS) offer a way to cut down on trade in illegal fish with basically ensuring that: fish shipments are certified by national authorities as being caught legally and in compliance with best practices; certified hard-copy documentation accompanies the fish through processing and marketing nationally or internationally. Only fish with valid documentation can be exported or traded to markets where a CDS requirement exists. Until recently, the few such schemes that had been established mainly focused on overexploited high-value species, such as Chilean Seabass harvested in Antarctic waters, or Atlantic and Southern Bluefin Tuna.With seafood trade at record highs along with rising consumer demands, CDS could be more widely applied. Since 2010, the European Union has used a CDS that covers all imported fish shipments from overseas; and in 2016, the United States announced its own scheme. International buy-in critical One challenge facing broader use of CDS is logistically ensuring that a paper certificate safely makes it from a fishing port in one country to an inspection station in another. The new guidelines recommend that fish shipment information be recorded digitally for referencing at any point along the chain – reducing administrative burdens and cutting down on fraud opportunities. The new guidelines also call for “user friendly” CDS that are relatively simple and can be adapted to different fisheries circumstances. “CDS will only succeed if there is strong, international coordination,” explains Audun Lem, Deputy-Director of FAO’s Fisheries and Aquaculture Policy and Resources Division and current Secretary of FAO’s Sub-Committee on Fish Trade. “Although they are voluntary, the process of negotiation that led to the new guidelines means they enjoy a high level of buy-in by governments, while endorsement at the FAO Conference will send a clear signal of commitment to adhere to them. So, going forward, new catch documentation schemes established at the national, regional or international level will be in sync, reducing barriers to their wider use,” he underscored. Additionally, Mr. Lem added that because the guidelines call on countries to comply with existing international laws as well as World Trade Organization agreements, their developing CDS will allow countries to avoid unwanted trade disputes. Fish caught in the Seychelles. Photo: UNEP GRID Arendal/Lawrence Hislop “A set of draft Voluntary Guidelines on Catch Documentation Schemes was last week unanimously adopted by a FAO technical consultation that brought a five-year negotiation effort to a close, and are now poised for adoption by all UN Food and Agriculture Organization (FAO) members at [its] upcoming bi-annual governing conference,” the agency said in a news release. Once approved by the Conference, which will take place in Rome from 3 to 8 July, the guidelines will act as an internationally-recognized “gold standard” reference for governments and businesses looking to establish systems that can trace fish from their point of capture through the entire supply chain, in other words from “sea-to-plate,” to stop illegally caught fish from entering the marketplace.Globally, some 91-93 million tonnes of fish are captured each year, and seafood products are among the world’s most widely traded food commodities – with a $142 billion export value in 2016. Illegal, unreported and unregulated fishing is also estimated to strip as much as 26 million additional tonnes of fish from the oceans annually, damaging marine ecosystems and sabotaging efforts to sustainably manage fisheries.
A devoted father taught himself biotechnology after his baby son had to have his arm amputated.Unsatisfied with the “cumbersome” options available for children and babies on the NHS, the psychology teacher locked himself in his shed for days on end to make the perfect bionic arm for his little boy.Arms with sensor technology, according to Ben Ryan, aren’t available until children are three or four years old, and he “wanted it a bit quicker than that”. Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. He has been working closely with Paul Sohi from software company Autodesk, who is impressed the dad was able to self-teach himself to make a bionic arm for his child.Mr Sohi said: “It’s been inspiring to work on this innovative and ambitious project.It is amazing that, despite Ben having no background in product design, he’s taught himself enough to create something that will not only help his own son Sol, but potentially lots of others facing the same challenges too.” He said that even rudimentary and cumbersome technology isn’t available until children are older.Mr Ryan, who is from Bangor, also revealed the current, antiquated prosthetic limbs being offered were ‘ugly’ and are often rejected by young children early on.Baby Sol, born in March 2015, had his arm amputated at just ten days old because of an unexpected clot in his arm.He gurgled happily on Good Morning Britain and used his new arm as his father spoke about the project. His wife, Kate, was worried about her husband’s mental health when he holed himself away in the shed to create the arm.”He was in his shed at the bottom of the garden and I wouldn’t see him for days”, she said.”To be perfectly honest I thought he was going a little bit mad.”When it’s working, he can make the thumb move”.Mr Ryan is crowdfunding to raise money for the baby bionic arms, and seems confident about the results. He said: “This is the second version I’ve made…and the next one I make will be better”. We’re joined again by little Sol, who had a bionic arm made for him by his daddy – and he’s getting on well with our scripts! pic.twitter.com/1j549Hvwp4— Good Morning Britain (@GMB) March 2, 2017 The father wants to help amputee babies around the world, writing on his crowdfunding page: “My aim through Ambionics is to help children everywhere adopt and continue to use prosthetics through into adulthood.”
Apple has always preferred to offer consumers a locked-down, end-to-end experience. That’s what makes the iPad one of the most enjoyable consumer mobile devices, but also perhaps the most restrictive. Since the original iPhone, the jailbreak community has been cracking the software in iDevices to give users more flexibility with advanced apps. This time app developers have taken things to a new level. Quasar is an impressive window management system for iPads.We’re all used to the multi-window paradigm on desktop PCs, but that has never worked quite right on a touchscreen device. Multitasking on mobile devices has just meant suspending an app in the background so it can be returned to quickly. Quasar actually makes your iPad apps behave like real windows. You can resize, move, minimize, and close them as you like.Each app has a bar across the bottom that you can use to change the size, close, full screen, and rotate it. The rotation support literally made me say “whoa” out loud. The apps behave just like they are getting rotation information from the accelerometer. The interface changes to the correct landscape or portrait UI and it’s really smooth. Quasar also plugs into the iOS multitasking bar for easy switching between windowed apps.This is a great way to keep multiple things going at once, and finally gives you a use for all those iPhone-only apps that scale poorly to the iPad. The app is still in the early phases of public availability so there are probably going to be bugs, and I assume battery life is going to take a hit. Although, it might be worth the risk to try it out.Quasar is available in the Cydia store for jailbroken iPads, and it can be yours for $9.99.via TheBigBoss
G8 de l’Internet : Zuckerberg, Schmidt et Bezos seront à ParisLes patrons des trois géants américains Facebook, Google et Amazon participeront à l’e-G8 organisé les 24 et 25 mai à Paris, indique la page Facebook de Nicolas Sarkozy.”Liberté, croissance économique, éducation : sur toutes les questions liées à Internet viendront échanger les grands acteurs français et européens ainsi que des figures internationales comme Mark Zuckerberg (Facebook), Eric Schmidt (Google) ou Jeff Bezos (Amazon)”, peut-on lire sur la page Facebook du président de la République. Le message ajoute : “Je me réjouis que de nombreux leaders du monde d’Internet aient répondu à l’invitation de la France pour venir débattre d’internet au e-G8 Forum les 24 et 25 mai”.À lire aussiFacebook, Star Wars et Apple, les actus sciences que vous devez connaître ce 23 juinCe sommet devrait rassembler entre 800 et 1.000 acteurs de l’Internet, opérateurs de télécoms, équipementiers et producteurs de contenus, selon le président du directoire de Publicis, Maurice Lévy, chargé par Nicolas Sarkozy d’organiser l’événement. Ce dernier indique que le forum a avant tout pour objectif de “voir comment Internet, le numérique et la communication mobile peuvent accélérer la croissance dans les pays développés”, rapporte l’AFP.Plusieurs séances plénières sont prévues sur différents thèmes comme “Internet et la croissance économique”, l’impact d’Internet “sur la société les loisirs, les marchés, les modes de communications ou encore l’éducation”, “l’avenir de l’Internet” ou encore “la propriété intellectuelle dans l’ère numérique”.Cet e-G8 se tiendra la veille du traditionnel sommet des chefs d’Etat et de gouvernement, prévu à Deauville les 26 et 27 mai.Le 13 mai 2011 à 18:20 • Emmanuel Perrin
Stay on target Sorry, You Can’t Date Keanu Reeves in ‘Cyberpunk 2077”Star Wars Pinball’ Has Your Favorite Brand in Ball Form October is officially the wallet-murdering month. As it usually does during this time of year, the game industry has once again decided to drop a metric ton of AAA games in time for the holiday rush. This is great if you’re looking for new titles to play, but crappy if you have a small budget. With that said, even if you only pick up a title or two in October you’re still getting something worth playing. Worst-case, scenario, you can circle back to these games when Black Friday hits. Seriously, there’s a lot of gold here that you do not want to miss out on.Red Dead Redemption 2Platform: PlayStation 4, Xbox OneRelease date: October 26Without a doubt, the biggest game releasing this month is none other than Red Dead Redemption 2. Rockstar Games’ Western epic looks like a huge improvement over the original; which says a lot considering how expertly realized that experience was. While it’s true that the game has been in development for a long time, it looks like it’ll be worth the long wait. Everything we’ve seen so far looks absolutely amazing.The only drawback for some might be the fact Red Dead Redemption 2 will not launch with a multiplayer mode. Folks will have to wait for a beta releasing in November for a chance to shoot others online. Personally, I’m not bothered by this. I’m more invested in the feature-rich campaign than the online mode. That isn’t to say I am not looking forward to forming a posse with friends. I am, but I really just want to play the story.You can pre-order Red Dead Redemption on Amazon.Mega Man 11Platform: PC, PS4, Switch, Xbox OneRelease date: October 02Another long-awaited title releasing in October is Mega Man 11. There’s been a lot of drama surrounding the Mega Man franchise for the past few years. In fact some (myself included) didn’t think we’d ever see a new entry this generation. Thankfully, Capcom has finally released a new game starring the Blue Bomber.As I said in my review, Mega Man 11 is a return to form that also pushes the franchise forward. It has the classic gameplay fans have come to love, but it also introduces the new Double Gear system which perfectly complements the core mechanics. Mega Man 11 even has a bit more story than usual, which is a nice addition. I hope this is the start of a full-on Mega Man revival. The world needs the little android now more than ever, as far as I’m concerned.You can buy Mega Man 11 on Amazon.Fist of the North Star: Lost ParadisePlatform: PS4Release date: October 02The most surprising release of October (and perhaps 2018) is Fist of the North Star: Lost Paradise. I don’t think I’m alone in saying I never expected a FotNS game developed by the team behind the Yakuza series. Essentially, this is a Yakuza game with a different skin, but it certainly satisfies fans of the classic anime/manga series. Anime-based games are hit or miss. Thankfully, Lost Paradise is a great game through and through.There isn’t more I can say about this title that I didn’t already discuss in my review. Fist of the North Star: Lost Paradise is simply a fun experience. The game displays the versatility of both the Yakuza game engine of the FotNS franchise. I hope we get a full-on offshoot franchise after this. But as I said in my review, I’d like the sequel to run on the Yakuza 6 Dragon Engine. We’ll see what happens, but I hope Sega doesn’t miss an opportunity to give the world another great series. Also, Fist of the North Star deserves this kind of treatment in video games. Keep ‘em coming, I say!You can buy Fist of the North Star: Lost Paradise on Amazon.Assassin’s Creed OdysseyPlatform: PC, PS4, Xbox OneRelease date: October 05I know it’s cool to hate on Assassin’s Creed, but I’m not down with that. I have no shame in professing my love for Ubisoft’s historically-minded franchise. No other series combines enjoyable Action Adventure mechanics with real-world history quite like this. Some entries are better than others, but more often than not, Assassin’s Creed games deliver the goods. This is certainly true of Assassin’s Creed Odyssey.This game is set in Ancient Greece during the Peloponnesian War. Based on what I played, it takes the best elements from Assassin’s Creed IV: Black Flag and Assassin’s Creed: Origins. As a huge fan of Ancient Greece, this could potentially become my favorite entry in the series. Every game set in this era usually focuses on the myths and legends. Odyssey will present a realistic depiction of Ancient Greek life, which should be a nice change of pace. Words cannot express how excited I am to play the full game.You can pre-order Assassin’s Creed Odyssey on Amazon.Soulcalibur VIPlatform: PC, PS4, Xbox OneRelease date: October 19Fighting games have enjoyed a rise in popularity in recent years thanks to games like Injustice 2, Dragon Ball FighterZ, Tekken 7, and several others. Now that the land is ripe for fighters, it’s fitting that the long-dormant Soulcalibur awakens from its slumber. As the premier weapons-based fighting game, Soulcalibur VI should be a huge title among the fighting game community.Soulcalibur VI is a return to form for the franchise. It is both a (somewhat) remake of the original Dreamcast game and a completely new entry. I guess the term “soft reboot” applies here. Players can certainly expect the same high-level weapons-based combat the series is known for, along with its colorful cast of characters. This will definitely be a fun game to watch others livestream.You can pre-order Soulcalibur VI on Amazon.Forza Horizon 4Platform: PC, Xbox OneRelease date: October 02If you’re a racing game fan, then you’re likely looking forward to playing Forza Horizon 4. Fundamentally, this delivers the same experience of previous entries. This isn’t a problem considering how fine-tuned (pun intended) the driving mechanics are. The big new feature for this installment is dynamic seasons. Driving in the summer is a completely different experience from cruising during the winter. This adds a whole new level of challenge which players will surely love.While I appreciate the Forza Horizon series, I can’t say I’m particularly excited when a new one releases. Like I said before, I’m not exactly keen on giant open-world games these days… even if it is a racer. Also, I’m still salty EA hasn’t given us a new Burnout Paradise. I know it’s unfair to other racers, but for me, I don’t want to play a big open-world racing game unless it’s Burnout. For everyone else, if you want a solid racing game experience, Forza Motorsport 4 more than satisfies.You can buy Forza Horizon 4 on Amazon.Call of Duty: Black Ops 4Platform: PC, PS4, Xbox OneRelease date: October 12Call of Duty games are notorious for being multiplayer-focused but Black Ops 4 takes things further by completely omitting the single player campaign. Seeing as how most Call of Duty fans only play online, this is probably not going to be a major issue. Besides that, this is the same Call of Duty experience fans have come to expect. Well, that is except for one major new addition…The Call of Duty series is throwing its hat into the battle royale ring with the addition of Blackout mode. This mode features the same basic last-man-standing gameplay popularized by PUBG and Fortnite. The inclusion of this mode has caused some division within the community. CoD players either love it or hate it. There doesn’t seem to be much middle ground. It’ll be interesting to see how the larger community takes to Blackout mode (and the game overall) when Black Ops 4 releases.You can pre-order Call of Duty: Black Ops 4 on Amazon.Super Mario PartyPlatform: Nintendo SwitchRelease date: October 05The biggest Nintendo Switch game of the month is Super Mario Party. Players can expect up to 80 different types of mini-games. Players can consider playing this title a workout regimen considering how the games take heavy advantage of the joy-con controllers. If you’re a fan of previous Mario Party titles then this one should be a no-brainer.You can pre-order Super Mario Party on Amazon.Lego DC Super-VillainsPlatform: PC, PS4, Switch, Xbox OneRelease date: October 16Lego games are always fun, and Lego DC Super-Villains is no exception. As the title states, this game focuses on DC’s super-villains, including Joker, Lex Luthor, Harley Quinn, Killer Croc, Poison Ivy, and many more. Based on what I played at E3, this game is every bit as fun as previous Lego titles. It might actually be more enjoyable since you now get to play as the bad guys. Lego DC Super-Villains is great for both kids and adults.You can pre-order Lego DC Super-Villains on Amazon.Let us know what you like about Geek by taking our survey.