OAKLAND — There’s something missing from the national conversations and narratives surrounding the NBA playoffs, and, frankly, it blows my mind.After all, it’s present on every single possession.Folks, we need to start talking about defense.As much as the postseason is a moment for shot creators and shot takers, a basket prevented is as good as a basket made. And while defense isn’t sexy, and most people don’t fully understand its nuances, it’s what separates good teams from …
South African-born scientist Dr Peter Jones has pioneered a new form of cancer treatment called epigenetic therapy. MEDIA CONTACTS • Dr Peter Jones University of Southern California +1 323 865 0816 USEFUL LINKS • USC/Norris Comprehensive Cancer Centre • Stand Up To Cancer • Cancer Association of South Africa RELATED ARTICLES • Rooibos yoghurt fights cancer • Vaccine hope for SA women • Top award for Rhodes scientistSamson MulugetaSouth African-born scientist Dr Peter Jones, who conducted his seminal research at Stellenbosch Medical School in the late 1970s, has pioneered a new form of cancer treatment called epigenetic therapy.Instead of killing cancer cells with chemotherapy or radiation, the new form of therapy activates dormant genes in the affected cells and instructs them to become healthy again.During an international clinical trial, the new type of therapy was found to boost some patients’ survival rate from 26% to 50%. The results were published in the British medical journal Lancet in March 2009.Jones emigrated to US in the 1980s and is currently a professor of urology, biochemistry and molecular biology at the University of Southern California.Together with Dr Stephen Baylin of the Sidney Kimmel Comprehensive Cancer Centre at Johns Hopkins University in Baltimore, he has formed the Dream Team project, which aims to bring the promise of epigenetic therapy to clinical practice. The focus of the project, made possible with a US$9.12-million (R73-million) grant, is on breast, colon and lung cancers as well leukaemia.Jones and Baylin’s effort is funded by Stand Up To Cancer, a US-based charity that supports research on new cancer treatments.Accidental discoveryBorn in Cape Town, Jones received a BSc in biochemistry from the University College of Rhodesia, now the University of Zimbabwe, in 1969, and a PhD in biochemistry from the University of London in 1973. He was a postdoctoral research fellow at the Children’s Hospital in Los Angeles, California, from 1973 to 1975.During his stint at Stellenbosch Medical School Jones tried to see whether cancer drugs could trigger cancer in basic – as opposed to specialised – human cells. During this investigation, quite by chance, he and a graduate student found that a basic human cell, once treated with a little-known drug called “aza-c”, started to beat, like a heart.The aza-c had somehow switched on the cell’s genes, turning it into a specialised muscle cell.This gave Jones the idea that the drug could ”turn off” genes in cancerous cells and transform them into healthy ones.“I can still remember being there in the lab at Tygerberg when my grad student ran in and said, ‘My God, I just saw these cells twitching.’ It was completely accidental,” Jones told the Sunday Times.Cancer drugs that have developed from the initial aza-c findings have shown promise in treating acute myelogenous leukaemia and a group of diseases called myelodysplastic syndromes.New field of scienceJones’s work has attracted a number of accolades. In 2008 he was awarded South Africa’s highest cancer research award, the AG Oettle prize, and in 2009 he scooped the prize for basic cancer research from the American Association for Cancer Research and the Kirk and Dorothy Landon Foundation.“It’s very rare in science that you can say the work of individual investigators revolutionises cancer research, but Peter Jones and Stephen Baylin have achieved that kind of paradigm shift,” said Margaret Foti, the association’s chief executive officer.“Their work has changed the way we view molecular causation from a genetic to an epigenetic focus. The potential impact of this work is enormous, and it is already resulting in significant improvements in cancer diagnosis and therapy.”Dr Carl Albrecht, head of research for the Cancer Association of South Africa and a former colleague, said Jones’s work represented “the great new hope” in the war on cancer.“I would not be surprised in the least if Jones were to win the Nobel Prize,” Albrecht told the Sunday Times. “This could prove to be one of South Africa’s greatest gifts to the world,” he said.Jones said the work he began while in South Africa led to a “whole new field of science in the world”.“Something was done in South Africa that has launched a serious new hope,” he said.
Share Facebook Twitter Google + LinkedIn Pinterest DuPont Pioneer today announced 12 new Pioneer® brand T Series soybean varieties with Roundup Ready 2 Xtend™ technology that will be available for pre-ordering this fall in the United States. The products are being made available for pre-orders in anticipation of a commercial launch of the trait for 2016 planting, pending applicable regulatory reviews.“Pioneer® brand soybeans with Roundup Ready 2 Xtend™ technology will provide farmers an improved way to manage tough-to-control weeds while delivering the outstanding yield and service they expect from Pioneer,” said Steve Reno, DuPont Pioneer vice president, regional director – U.S. & Canada. Soybeans with Roundup Ready 2 Xtend™ technology will enable applications of labeled dicamba herbicides, pending herbicide registration, as well as glyphosate herbicides. Dicamba herbicides will provide farmers a new way to manage tough-to-control and glyphosate-resistant broadleaf weeds such as waterhemp, marestail and palmer amaranth.“DuPont Pioneer sales, agronomy and seed production teams have been gearing up to launch the new trait in Pioneer soybeans,” said Reno. “We will have the agronomic data to help our customers get the right products on the right acres to meet their needs and the product volumes to support what we anticipate to be the largest soybean product launch in our history.”Soybeans with Roundup Ready 2 Xtend™ technology are approved for food, feed and cultivation in the United States and Canada. Sale and delivery of Pioneer® brand soybeans with Roundup Ready 2 Xtend™ technology will be completed once applicable regulatory reviews are concluded.Reno noted that if Roundup Ready 2 Xtend™ technology is not commercially launched in time for the 2016 crop year, Pioneer expects to have good supply of other elite soybean varieties to meet the needs of its customers who have pre-ordered varieties with Roundup Ready 2 Xtend™ technology.AUDIO: The Ohio Ag Net’s Ty Higgins visited with DuPont Pioneer’s Business Director Randy Minton about the launch of new soybean varieties with RR2X technology.Ty’s Wrap for Friday
Top Reasons to Go With Managed WordPress Hosting The basis of this system was an ontology that described how World Cup facts related to each other. For example, “Frank Lampard” was part of the “England Squad” and the “England Squad” competed in “Group C” of the “FIFA World Cup 2010”. The ontology also included “journalist-authored assets” such as stories, blogs, profiles, images, video and statistics.The publishing platform had both manual and automated tagging features. BBC journalists could, for example, tag Frank Lampard in a story about the disallowed goal from England’s last-16 loss against Germany. This is a normal part of most modern-day publishing systems (we tag content in this manner here at ReadWriteWeb). But the BBC World Cup site also automatically analyzed journalist content and matched it “against the World Cup ontology.” It did this by using what it describes as a “natural language and ontological determiner process.” [Update: IBM wrote in to inform us that the technology behind this was IBM LanguageWare.] This is similar to software such as Thomson Reuters’ Calais or the new Extractiv product that we reviewed yesterday. In the BBC’s case, the resulting tags were moderated before being published. Related Posts Why Tech Companies Need Simpler Terms of Servic… The BBC used Semantic Web technologies such as RDF and SPARQL to build their World Cup site. The stated goal was to achieve “intelligent mapping of journalist assets to concepts and queries.” The site reportedly served millions of page requests a day throughout the World Cup. The BBC may use this semantic publishing platform for other parts of the BBC sports site; and it will certainly deploy it again for the the London 2012 Olympics.The official explanatory post has the technical details, should you wish to follow up. Let us know in the comments about other large scale Semantic Web deployments that you know of.Update: See also The World Cup and a call to action around Linked Data, by the BBC’s John O’Donovan. Thanks Georgi Kobilarov for the pointer. Semantic Web Adoption by Facebook, Best Buy & OthersIt’s All Semantics: Open Data, Linked Data & The Semantic WebThe State of Linked Data in 2010Top 10 Semantic Web Products of 2009ReadWriteWeb Interview With Tim Berners-Lee The BBC World Cup site featured over 700 webpages and was powered by a semantic publishing framework. The site boasted a comprehensive ontology (a map of concepts), that output “automated metadata-driven web pages” created on-the-fly.Jem Rayfield, Senior Technical Architect, BBC News and Knowledge, explained further:“The underlying publishing framework does not author content directly; rather it publishes data about the content – metadata. The published metadata describes the world cup content at a fairly low-level of granularity, providing rich content relationships and semantic navigation. By querying this published metadata we are able to create dynamic page aggregations for teams, groups and players.” A Web Developer’s New Best Friend is the AI Wai… Tags:#NYT#Semantic Web#Structured Data#web The soccer World Cup has now ended, with Spain the victor. England was unceremoniously dumped out before the quarter finals – but if there was a World Cup for the Semantic Web, then the BBC may have lifted the trophy for its country. A post on the BBC Internet site explains how the BBC World Cup 2010 website used “dynamic semantic publishing” technology.It’s an impressive demonstration of how a large, mainstream website can have added meaning and structure.ReadWriteWeb’s Guide to The Semantic Web: richard macmanus 8 Best WordPress Hosting Solutions on the Market
How much money have you invested in your personal growth or development this year? How much money have you invested in your professional development? What is your growth and development budget?How much time have you spent on personal growth? How much time have you spent in the gym, the road, or the yoga studio working on your physical health and well-being? How much time have you spent with a book in your hands? How much time have you spent with video or audio programs?How much energy have you invested in your future? How much energy have you devoted to setting your goals, developing your plans, and working on building the life you want for yourself? How much energy have you spent in introspection, thinking about who you are and what you are here to do?You pay for your future now. You pay for that future with money, time, and energy. Success is something that you always have to pay for in advance. First, you do the lonely work of developing yourself and your ability to create value, and then you get the success that naturally follows. But if you aren’t paying now, you are right now deciding on your future regrets.Would the amount of money you spend on your personal and professional growth provide clear evidence that you are paying the price now for who you are going to be in the future?Would the time you spend hitting the gym, the time you spend hitting the books, or the time you spend in downward-facing dog make the case that you are working on you?Would the amount of energy you expended working on your goals, developing your plans, and bringing that future version of yourself to fruition be evident if you stood before a jury of your hustler peers?The safest and surest bet you can make is the bet you make on yourself. If you are going to make an investment, no other investment on Earth is going to produce greater returns now and in the future.
NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers The Cavaliers scored 43 points in the first quarter, but then went almost 6½ minutes without scoring in the fourth. They played the second half without coach Tyronn Lue, who went to the locker room in the second quarter with what the team said was an illness.“It’s like right now, when we hit adversity, we go our separate ways,” guard Isaiah Thomas said. “And that’s just how I feel and it looks like that as well.”The Magic made their first 10 shots of the second half and won consecutive games for the first time since Nov. 8-10.James did not have a rebound or an assist in a foul-plagued second half.“I gave my teammates some opportunities to knock ’em down, but they just didn’t go. You can’t get assists when they don’t go down, but that doesn’t stop me from finding my guys on the floor,” he said. “At this point it’s not what you say, it’s what you do. We’ve got to go out and play well as a collective group, everyone hitting at the right time on all cylinders, and right now we’re not doing that.”ADVERTISEMENT John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Ingram, Randle lead Lakers over Suns Globe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH Read Next The Cavaliers fell apart in the second half and lost for the 14th time in 21 games. They have given up an average of 122.4 points in their last five losses.“I couldn’t give up on my teammates like that. I just couldn’t do it,” James said after scoring 25 points. “We put too much into the game every single day.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutout“This is no time to be ashamed about our season,” he added. “We’ve got quite a few games left. If we’re still serious about the season, then we’ve got to play some good ball at some point.”Jonathon Simmons scored 22 of his career-high 34 points in the third quarter for the Magic, who broke a nine-game home-court losing streak against Cleveland. Simmons made seven of eight shots in his 22-point quarter, finishing the period with a 3-point buzzer shot in a game in which he almost did not play because of a sprained right ankle.“To be honest, adrenaline was just going and I didn’t even realize what was going on,” Simmons said. “I was just trying to play hard and trying not to have another setback.”J.R. Smith made three 3-pointers in the first four minutes to help the Cavaliers (30-22) take a 15-4 lead, and they led by 21 points late in the first half.Jeff Green dunked to put the Cavaliers up 61-40 with 4:50 left in the half, but they went scoreless for almost four minutes while the Magic (17-36) sliced nine points off the lead.James opened the second half with a couple of 3-pointers to regain a 16-point lead for Cleveland, but Simmons scored 12 points during the Magic’s 19-2 run that gave them their first lead of the game at 78-77 with 5:33 left in the third quarter.James was called for his fourth foul just 17 seconds later and sat for more than seven minutes.When he re-entered the game with 10:10 remaining in the fourth quarter, the Magic ran off 14 straight points to lead 108-92.Dwyane Wade banked in a 3-pointer for Cleveland’s only points in the first 7:25 of the fourth quarter.TIP-INSCavaliers: Wade missed the morning shootaround with an illness but played 22 minutes.Magic: Simmons’ 22-point quarter was three points short of the franchise record set by Tracy McGrady in 2003. … F Aaron Gordon missed a fifth straight game with a strained left hip flexor and has withdrawn from the Slam Dunk Contest at NBA All-Star Weekend.UP NEXT Cavaliers: Host Minnesota on Wednesday.Magic: Host Atlanta on Thursday. MOST READ Trending Articles PLAY LIST 00:50Trending Articles00:59Sports venues to be ready in time for SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City LATEST STORIES Brace for potentially devastating typhoon approaching PH – NDRRMC Slow and steady hope for near-extinct Bangladesh tortoises Cleveland Cavaliers forward LeBron James, rear, and center Tristan Thompson defend against Orlando Magic forward Jonathon Simmons during the second half of an NBA basketball game Tuesday, Feb. 6, 2018, in Orlando, Fla. The Magic won 116-98. (AP Photo/Phelan M. Ebenhack)ORLANDO, Fla. — After another embarrassing defeat and two days before the trade deadline, LeBron James let it be known he’s not going anywhere, at least for now.“I’m here for this season right now to try and figure out a way we can still compete,” James said after his Cleveland Cavaliers blew a 21-point lead in a 116-98 loss to the Orlando Magic. “I owe it to my teammates to finish this season out no matter how it ends up. I would never waive my no-trade clause.”ADVERTISEMENT Typhoon Kammuri accelerates, gains strength en route to PH Don’t miss out on the latest news and information. AFP official booed out of forum 2 ‘newbie’ drug pushers fall in Lucena sting View comments
S.K. Wankhede (left) and N.K.P. Salve: Power struggleOf all the sports organisations in this country, the Board of Control for Cricket in India (BCCI) is possibly the richest. Last fortnight, however, the riches had created a problem: the simple matter of a cheque for Rs 35 lakh – the proceeds,S.K. Wankhede (left) and N.K.P. Salve: Power struggleOf all the sports organisations in this country, the Board of Control for Cricket in India (BCCI) is possibly the richest. Last fortnight, however, the riches had created a problem: the simple matter of a cheque for Rs 35 lakh – the proceeds of the Delhi Test between India and the MCC last year – which should have gone to the BCCI account in Madras, but instead went into a fresh fixed deposit account in Bombay.Over half-a-dozen of the 28 BCCI members asked for details of the cheque’s curious progress. Jagmohan Dalmiya, honorary secretary of the Bengal Cricket Association, wrote to M.A. Chidambaram, BCCI treasurer, asking if any board official or working committee member had approved the opening of the account for such a huge amount – according to BCCI rules no new bank account can be opened without the board’s approval.The Delhi Test was handled by a special committee appointed by the BCCI, because the Delhi and District Cricket Association (DDCA) had been superseded. BCCI President S.K. Wankhede headed the committee, I.S. Bindra, president of the Punjab Cricket Association was convenor and P.M. Rungta of Rajasthan was treasurer. As there was no permanent body in Delhi to look after the record profit of Rs 35 lakh, it was resolved that the money would be transferred to the BCCI’S account in Madras. According to Bindra, he along with Rungta wrote a cheque for Rs 35 lakh on February 5, 1982 in favour of the BCCI.advertisementBut instead of handing the cheque to Chidambaram, Rungta inexplicably withdrew the money from the Tolstoy Marg branch of the New Bank of India and converted it into a demand draft – No 434072/78/82 dated February 6, 1982 – drawn on the bank’s Bombay branch – Bindra was not in on this. In a letter to the bank, Rungta wrote: “Please issue a demand draft in the name of Board of Control for Cricket in India payable at Bombay.” On the same day, as it happened, an account was opened in the Banque Nationale de Paris and a fixed deposit of Rs 35 lakh for one year was made in the name of the BCCI. Chidambaram received a fixed deposit receipt from Rungta, instead of a cheque.Disputed Matters: The matter was first raised at the working committee meeting on April 1, 1982. Some pointed questions remained unanswered: why Rungta converted the cheque into a draft on his own; why a foreign bank was preferred, especially when the rate of interest – 7.5 per cent – is the same as that of Indian banks; who endorsed the account papers as only the BCCI president and/or treasurer can operate an account and that too after a BCCI resolution; and how the bank opened an account in the name of an organisation without asking for the resolution and the memorandum of association.The group that has talked the most about Rungta’s initiative is the “anti-Bombay group’, and consists mostly of senior government officials like Bindra, Phalgum Matilal, a joint director in the Railway Ministry, Kamlesh Sharma, a joint secretary in the Union Home Ministry and S.K. Kakkar, a senior Chandigarh administration official.They are powerfully backed by Minister of State for Information N.K.P. Salve, Jammu & Kashmir Chief Minister Farooq Abdullah and Kamal Nath, the powerful MP who dislodged K.K. Mehra and his friends from the DDCA. Kakkar says that “there is ample scope for smelling a rat” and feels that the bank “might have used the cash for sanctioning loans to various firms” in the wake of the credit squeeze.In the August 16-17 meeting of the BCCI in Bombay, this group demanded that the Central Bureau of Investigation investigate the matter and that the account be closed. But Rungta was not present and a decision was postponed. For his part, Rungta refutes the allegation that there was anything wrong in opening the account.Said he: “Bindra signed a cheque and gave it to me to be handed over to the treasurer of the board. It is also correct that I handed over the demand draft receipt to Chidambaram.” He also claimed that the new account was opened in consultation with the treasurer and the president. But both Chidambaram and Wankhede, when asked in the board meeting, did not accept that they knew about it earlier.Financial Problems: ‘Irregularities’ in financial procedures have occurred earlier. Dalmiya had pointed out 54 errors in the audited accounts for 1980-81. The general body meeting in Bangalore on September 28, 1981, took note of his objections which included: glaring discrepancies in the cash and bank balances in accounts presented by the treasurer to the BCCI working committee on August 3, 1980 and figures given out at the Bangalore meeting; Rs 26 lakh expenditure on the Golden Jubilee Test between India and England at Bombay when only Rs 11 lakh was approved; unexplained expenditure of Rs 2 lakh in foreign exchange in England during the 1979 tour; and investment of nearly Rs 1 crore in various private companies by the BCCI investment committee without the approval of the BCCI board or working committee.advertisementThis last provoked quite a furore at two meetings of the board. According to the statement of accounts for 1980-81, the private companies so favoured are Tata Oil Mills (Rs 10 lakh), Mahindra and Mahindra (Rs 25 lakh), Bayer India Ltd (Rs 15 lakh), Standard Oil Mills (Rs 15 lakh) and ITC Ltd (Rs 25 lakh). The money came from nationalised banks by prematurely cancelling fixed deposits, and board officials accepted that the board or the working committee did not authorise the withdrawal and that the terms and the conditions were not disclosed earlier. Wankhede and others claimed, however, that no BCCI office-bearer was connected with any of the companies. Only after Dalmiya persisted was an eight-member inquiry committee, headed by Wankhede, appointed to look into these allegations: the final report is still to come even after a year.Things are likely to come to a head on September 26, 1982, at the elections for the office-bearers. The ‘anti-Bombay group’ led by Bindra is determined to oust Wankhede and his men and they seem to have numbers on their side: at a recent meeting of their group 16 of the BCCI’s 28 members were present.They have reportedly decided to field Salve for the president’s post. Says Matilal: “Ours is a democratic fight. We don’t want politics and money to spoil Indian cricket; we want to cleanse the BCCI of unscrupulous elements.” A pitched battle is clearly in the offing.