South African-born scientist Dr Peter Jones has pioneered a new form of cancer treatment called epigenetic therapy. MEDIA CONTACTS • Dr Peter Jones University of Southern California +1 323 865 0816 USEFUL LINKS • USC/Norris Comprehensive Cancer Centre • Stand Up To Cancer • Cancer Association of South Africa RELATED ARTICLES • Rooibos yoghurt fights cancer • Vaccine hope for SA women • Top award for Rhodes scientistSamson MulugetaSouth African-born scientist Dr Peter Jones, who conducted his seminal research at Stellenbosch Medical School in the late 1970s, has pioneered a new form of cancer treatment called epigenetic therapy.Instead of killing cancer cells with chemotherapy or radiation, the new form of therapy activates dormant genes in the affected cells and instructs them to become healthy again.During an international clinical trial, the new type of therapy was found to boost some patients’ survival rate from 26% to 50%. The results were published in the British medical journal Lancet in March 2009.Jones emigrated to US in the 1980s and is currently a professor of urology, biochemistry and molecular biology at the University of Southern California.Together with Dr Stephen Baylin of the Sidney Kimmel Comprehensive Cancer Centre at Johns Hopkins University in Baltimore, he has formed the Dream Team project, which aims to bring the promise of epigenetic therapy to clinical practice. The focus of the project, made possible with a US$9.12-million (R73-million) grant, is on breast, colon and lung cancers as well leukaemia.Jones and Baylin’s effort is funded by Stand Up To Cancer, a US-based charity that supports research on new cancer treatments.Accidental discoveryBorn in Cape Town, Jones received a BSc in biochemistry from the University College of Rhodesia, now the University of Zimbabwe, in 1969, and a PhD in biochemistry from the University of London in 1973. He was a postdoctoral research fellow at the Children’s Hospital in Los Angeles, California, from 1973 to 1975.During his stint at Stellenbosch Medical School Jones tried to see whether cancer drugs could trigger cancer in basic – as opposed to specialised – human cells. During this investigation, quite by chance, he and a graduate student found that a basic human cell, once treated with a little-known drug called “aza-c”, started to beat, like a heart.The aza-c had somehow switched on the cell’s genes, turning it into a specialised muscle cell.This gave Jones the idea that the drug could ”turn off” genes in cancerous cells and transform them into healthy ones.“I can still remember being there in the lab at Tygerberg when my grad student ran in and said, ‘My God, I just saw these cells twitching.’ It was completely accidental,” Jones told the Sunday Times.Cancer drugs that have developed from the initial aza-c findings have shown promise in treating acute myelogenous leukaemia and a group of diseases called myelodysplastic syndromes.New field of scienceJones’s work has attracted a number of accolades. In 2008 he was awarded South Africa’s highest cancer research award, the AG Oettle prize, and in 2009 he scooped the prize for basic cancer research from the American Association for Cancer Research and the Kirk and Dorothy Landon Foundation.“It’s very rare in science that you can say the work of individual investigators revolutionises cancer research, but Peter Jones and Stephen Baylin have achieved that kind of paradigm shift,” said Margaret Foti, the association’s chief executive officer.“Their work has changed the way we view molecular causation from a genetic to an epigenetic focus. The potential impact of this work is enormous, and it is already resulting in significant improvements in cancer diagnosis and therapy.”Dr Carl Albrecht, head of research for the Cancer Association of South Africa and a former colleague, said Jones’s work represented “the great new hope” in the war on cancer.“I would not be surprised in the least if Jones were to win the Nobel Prize,” Albrecht told the Sunday Times. “This could prove to be one of South Africa’s greatest gifts to the world,” he said.Jones said the work he began while in South Africa led to a “whole new field of science in the world”.“Something was done in South Africa that has launched a serious new hope,” he said.
What it Takes to Build a Highly Secure FinTech … Tags:#Mobile Payments#now#square Related Posts The Rise and Rise of Mobile Payment Technology Square, the mobile payment service that has been making strong inroads within the North American retail sector, has announced the availability of its service in Japan. The company is already processing $15 billion in annualized payments, and this move into Asia is expected to greatly increase the popularity and profitability of the service. readwrite Role of Mobile App Analytics In-App Engagement Why IoT Apps are Eating Device Interfaces
NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers The Cavaliers scored 43 points in the first quarter, but then went almost 6½ minutes without scoring in the fourth. They played the second half without coach Tyronn Lue, who went to the locker room in the second quarter with what the team said was an illness.“It’s like right now, when we hit adversity, we go our separate ways,” guard Isaiah Thomas said. “And that’s just how I feel and it looks like that as well.”The Magic made their first 10 shots of the second half and won consecutive games for the first time since Nov. 8-10.James did not have a rebound or an assist in a foul-plagued second half.“I gave my teammates some opportunities to knock ’em down, but they just didn’t go. You can’t get assists when they don’t go down, but that doesn’t stop me from finding my guys on the floor,” he said. “At this point it’s not what you say, it’s what you do. We’ve got to go out and play well as a collective group, everyone hitting at the right time on all cylinders, and right now we’re not doing that.”ADVERTISEMENT John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Ingram, Randle lead Lakers over Suns Globe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH Read Next The Cavaliers fell apart in the second half and lost for the 14th time in 21 games. They have given up an average of 122.4 points in their last five losses.“I couldn’t give up on my teammates like that. I just couldn’t do it,” James said after scoring 25 points. “We put too much into the game every single day.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutout“This is no time to be ashamed about our season,” he added. “We’ve got quite a few games left. If we’re still serious about the season, then we’ve got to play some good ball at some point.”Jonathon Simmons scored 22 of his career-high 34 points in the third quarter for the Magic, who broke a nine-game home-court losing streak against Cleveland. Simmons made seven of eight shots in his 22-point quarter, finishing the period with a 3-point buzzer shot in a game in which he almost did not play because of a sprained right ankle.“To be honest, adrenaline was just going and I didn’t even realize what was going on,” Simmons said. “I was just trying to play hard and trying not to have another setback.”J.R. Smith made three 3-pointers in the first four minutes to help the Cavaliers (30-22) take a 15-4 lead, and they led by 21 points late in the first half.Jeff Green dunked to put the Cavaliers up 61-40 with 4:50 left in the half, but they went scoreless for almost four minutes while the Magic (17-36) sliced nine points off the lead.James opened the second half with a couple of 3-pointers to regain a 16-point lead for Cleveland, but Simmons scored 12 points during the Magic’s 19-2 run that gave them their first lead of the game at 78-77 with 5:33 left in the third quarter.James was called for his fourth foul just 17 seconds later and sat for more than seven minutes.When he re-entered the game with 10:10 remaining in the fourth quarter, the Magic ran off 14 straight points to lead 108-92.Dwyane Wade banked in a 3-pointer for Cleveland’s only points in the first 7:25 of the fourth quarter.TIP-INSCavaliers: Wade missed the morning shootaround with an illness but played 22 minutes.Magic: Simmons’ 22-point quarter was three points short of the franchise record set by Tracy McGrady in 2003. … F Aaron Gordon missed a fifth straight game with a strained left hip flexor and has withdrawn from the Slam Dunk Contest at NBA All-Star Weekend.UP NEXT Cavaliers: Host Minnesota on Wednesday.Magic: Host Atlanta on Thursday. 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Ebenhack)ORLANDO, Fla. — After another embarrassing defeat and two days before the trade deadline, LeBron James let it be known he’s not going anywhere, at least for now.“I’m here for this season right now to try and figure out a way we can still compete,” James said after his Cleveland Cavaliers blew a 21-point lead in a 116-98 loss to the Orlando Magic. “I owe it to my teammates to finish this season out no matter how it ends up. I would never waive my no-trade clause.”ADVERTISEMENT Typhoon Kammuri accelerates, gains strength en route to PH Don’t miss out on the latest news and information. AFP official booed out of forum 2 ‘newbie’ drug pushers fall in Lucena sting View comments
The project, slated for completion by early 2019, is being spearheaded by the school’s Home-School Association (HSA) and aims to provide additional space for the student population, which averages just under 1,700, as well as increase the use of technology in the school’s curriculum. Ground was broken today (June 19) for the construction of five additional classrooms and four technology laboratories at Immaculate Conception High School (ICHS) in St Andrew, at a cost of approximately $76 million. Story Highlights Education, Youth and Information Minister, Senator the Hon. Ruel Reid, who took part in the ceremony, said he welcomed the initiative, which he described as the school’s response to the Ministry’s call for more schools to be built and expanded to facilitate the provision of quality high-school education. Ground was broken today (June 19) for the construction of five additional classrooms and four technology laboratories at Immaculate Conception High School (ICHS) in St Andrew, at a cost of approximately $76 million.The project, slated for completion by early 2019, is being spearheaded by the school’s Home-School Association (HSA) and aims to provide additional space for the student population, which averages just under 1,700, as well as increase the use of technology in the school’s curriculum.Funding is being provided through a partnership involving the Ministry and private-sector stakeholders collaborating with the HSA.Education, Youth and Information Minister, Senator the Hon. Ruel Reid, who took part in the ceremony, said he welcomed the initiative, which he described as the school’s response to the Ministry’s call for more schools to be built and expanded to facilitate the provision of quality high-school education.“The excellence that you have at Immaculate is what we want for all students,” the Minister said.“We want universal access for all students… so that we have a population that is highly skilled, trained and certified. Not only will (this) add to the local productivity on the one hand, but, equally, we will be able to attract higher quality of investments into Jamaica, so that all of us can grow and prosper,” he added.Senator Reid also lauded ICHS’s administration for its outstanding work at the institution, which, he noted, has laid the foundation for the students’ success.“All of us are proud of your performance at this noble institution (which) has been stellar, and the Ministry wants to thank you as a school and church family for your commitment to education (and) what you have been doing in uplifting the lives of our young ladies,” he added.Meanwhile, President of the HSA, Donovan Mayne, said the project represents the first major building development undertaken at the school in approximately 20 years.Mr. Mayne thanked Senator Reid for committing the Ministry’s support for the undertaking, and also the various private-sector stakeholders partnering on the project. They include the NCB Foundation and Barita Investments.Additionally, Mr Mayne expressed gratitude to the staff and students, who were instrumental in raising approximately $4 million that will go towards the project.For her part, Principal, Sister Angella Harris, also welcomed the project’s implementation, which she said will further enhance the environment for the students’ development and their exposure to technology, thereby preparing them for substantive careers.
zoomIllustration; Image Courtesy: Pixabay under CC 2.0 license Nippon Yusen Kaisha (NYK) and Mitsubishi Logistics Corporation (MLC) intend to establish a joint holding company in December 2018 and merge port and transportation business companies in April 2019.Earlier this year, the duo unveiled plans to integrate management of the four NYK Group terminal operation companies in Japan through a new joint holding company and merge UNI-X Corporation (UNI-X) and Nippon Container Terminals (NCT).NYK Group companies for the management integration include UNI-X, NCT, Asahi Unyu Kaisha and Yusen Koun.To be located in Tokyo, the new holding company will be named MY Terminals Holdings Limited, owned 51% by NYK and 49% by MLC.What is more, the joint company of UNI-X and NCT will have a trade name UNI-X NCT Corporation. The company, owned by MY Terminals Holdings Limited, will also be based in Tokyo.NYK explained in August that the purpose of management integration is to consolidate quality improvement efforts and enhance long-term service stability for port and harbor transportation business.